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Unraveling the mechanisms of Schisandra Chinensis Mixture against diabetic nephropathy by integrating serum pharmacochemistry, network pharmacology, transcriptomics, and metabolomics

Bibliographic Data

ID14737016
AuthorsYuan-Yuan Deng (0009-0001-3946-6655, Beijing University of Chinese Medicine), Yu Ma (0009-0002-3861-9055, Beijing University of Chinese Medicine), Yixuan Wang (0000-0002-5084-2455, Beijing University of Chinese Medicine), Yi-Xuan Wang, Ling Wang (0000-0002-5015-7706, Beijing University of Chinese Medicine), Lu-Yao Wang (Beijing University of Chinese Medicine), Xinyu Ma (0000-0001-5732-2404, Tianjin Medical University), Xin-Yu Ma, Jiang-Yuan Jin, Jiangyuan Jin (Tianjin University of Traditional Chinese Medicine), Ni Tian (0000-0001-9993-9592, Tianjin University of Traditional Chinese Medicine), Shao-Ning Dong (Tianjin University of Traditional Chinese Medicine), Shuang Dong (0000-0002-8992-225X, Tianjin University of Traditional Chinese Medicine), Sai Zhang (0000-0002-6622-2592, Beijing University of Chinese Medicine, corresponding author), Minying Zhang (0000-0001-7461-7060, Tianjin University of Traditional Chinese Medicine, corresponding author), Min-Ying Zhang, Mian-Zhi Zhang (Tianjin University of Traditional Chinese Medicine, corresponding author)
Year2026
Volume359
Pages120983
Publication date2026-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120983
PMID41389885
OpenAlexW4417321171
LanguageEN
Citations received1
References cited70

Diabetes mellitus · Diabetic nephropathy · Glycerophospholipid · Lipid peroxidation · Mechanism (biology · Metabolic pathway · Metabolomics · Reprogramming · Schisandra chinensis · Ferroptosis and cancer prognosis · Immune cells in cancer · Inflammasome and immune disorders

  • Integrated network analysis, proteomics, and experimental validation reveal the mechanisms underlying the renoprotective effects of salvianolic acid A against diabetic nephropathy

    Open Access•Zheng Luo, Yu Ma•Journal of Ethnopharmacology•2026

  • Ferroptosis

    Open Access•Xuejun Jiang, Brent R Stockwell et al.•Nature Reviews Molecular Cell…•2021

  • Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic nephropathy

    Open Access•Yu Ma, Yuanyuan Deng et al.•Journal of Ethnopharmacology•2023

  • Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy

    Open Access•Mianzhi Zhang, Miao Liu et al.•Journal of Ethnopharmacology•2012

Unique citing works1
Citations per year1
Citation span2026 - 2026 (1)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 1

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