Ferroptosis
Mechanisms, biology and role in disease
Bibliographic Data
| ID | 23333151 |
|---|---|
| Authors | Xuejun Jiang (0000-0001-5861-5452, Memorial Sloan Kettering Cancer Center, corresponding author), Brent R Stockwell (0000-0002-3532-3868, Columbia University, corresponding author), Marcus Conrad (0000-0002-6352-9046, Helmholtz Zentrum München, corresponding author) |
| Year | 2021 |
| Volume | 22 |
| Issue | 4 |
| Pages | 266-282 |
| Publication date | 2021-04-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nature Reviews Molecular Cell Biology (JOURNAL) |
| Journal identifiers | ISSN: 1471-0072 • E-ISSN: 1471-0080 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/s41580-020-00324-8 |
| PMID | 33495651 |
| OpenAlex | W3123922203 |
| Language | EN |
| Citations received | 59 |
| References cited | 189 |
Apoptosis · Bioinformatics · Biology · Cancer · Cancer cell · Disease · GPX4 · Immune system · Lipid peroxidation · Mechanism (biology) · Oxidative stress · Pathology · Programmed cell death · Biochemistry · Cancer Research · Cancer, Lipids, and Metabolism · Cell Biology · Ferroptosis and cancer prognosis · Genetics · Immunology · Medicine · Neuroscience · RNA modifications and cancer
Development and Validation of a Novel Diagnostic Model for Childhood Autism Spectrum Disorder Based on Ferroptosis-Related Genes
Sex difference in the association between blood alcohol concentration and serum ferritin
Blood transcriptome analysis
Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis
Multi-omics integration reveals inhibitory effects of carbon ion radiation on lung adenocarcinoma proliferation
SPC25 Activates the Warburg Effect to Inhibit Ferroptosis in Prostate Cancer Cells
A qualitative exploration of patients experiencing traumatic stress and receiving eye movement desensitization and reprocessing (EMDR) therapy based on an adaptive information processing model in Jordan
Blockade of GPX4-mediated ferroptosis underlies the protective effect of Forsythiae Fructus water extract against poly(I
Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury
Β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the Mapk and STAT3 signaling pathways
The protective effect of Lonicera japonica Thunb. against lipopolysaccharide-induced acute lung injury in mice
Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy
Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway
A literature review on signaling pathways of cervical cancer cell death-apoptosis induced by Traditional Chinese Medicine
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis
Investigating the mechanism of Rehmannia glutinosa–Ephedra sinica in heart failure with preserved ejection fraction by network pharmacology, metabolomics and experimental validation
Swietenine improved the progression of diabetic nephropathy through inhibiting ferroptosis via activating Akt/GSK-3β/Nrf2 signaling pathway
Gentiopicroside activates Pink1-dependent mitophagy to inhibit ferroptosis and promote flap survival
Shenling Baizhu San improves spermatogenic dysfunction in hyperuricemia mice by regulating Sirt3/Nrf2 to inhibit testicular ferroptosis
Oleanolic acid 28-O-β-D-glucopyranoside alleviates TNBS-induced ulcerative colitis in rat by regulating Nrf2/x-CT/GPX4-mediated ferroptosis
Integration of metabolomics and transcriptomics reveals that Da Chuanxiong Formula improves vascular cognitive impairment via ACSL4/GPX4 mediated ferroptosis
Fuxin decoction regulates the Nrf2/SLC7A11/GPX4 pathway to ameliorate doxorubicin-induced ferroptosis in cardiomyocytes
Lizhong decoction ameliorates ulcerative colitis by inhibiting ferroptosis of enterocytes via the Nrf2/SLC7A11/GPX4 pathway
Taohong Siwu Decoction modulates glutathione metabolism to suppress hepatocyte ferroptosis and demonstrates anti-fibrotic effects in the liver
BaZiBuShen inhibition of oocyte ferroptosis in primordial follicles through activation of NF2-YAP pathway for the treatment of chemotherapy-induced premature ovarian insufficiency
Mechanistic insights into the ameliorative effects of Xianglianhuazhuo formula on chronic atrophic gastritis through ferroptosis mediated by YY1/miR-320a/TFRC signal pathway
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy
Neuroprotective effects of ZiYin XiFeng formula against Parkinson's disease via Nrf2/SLC7A11/GPX4-mediated ferroptosis inhibition
Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction
She ethnomedicine ameliorates ovarian dysfunction through enhanced cellular proliferation and anti-inflammation
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis
Gualou-Xiebai herb pair ameliorate atherosclerosis in HFD-induced ApoE−/− mice and inhibit the ox-LDL-induced injury of Huvecs by regulating the Nrf2-mediated ferroptosis
Buzhong yiqi decoction improves cisplatin resistance in non-small cell lung cancer by inhibiting PCBP1 to activate the ferritinophagy-mediated ferroptosis pathway
Mechanism of xihuang pill inhibition of SLC7A11 deubiquitination through downregulation of the Otub1 to promote ferroptosis in triple-negative breast cancer
Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis
Wu-Mei-Wan promotes ferroptosis in gallbladder cancer through STAT3 negative regulation
Unraveling the mechanisms of Schisandra Chinensis Mixture against diabetic nephropathy by integrating serum pharmacochemistry, network pharmacology, transcriptomics, and metabolomics
Cistanche attenuates acute kidney injury by inhibiting ferroptosis through the disruption of Keap1-Nrf2 interaction
Shenfu injection ameliorates hepatic ischemia-reperfusion injury through induction of ferroptosis via JAK2/STAT3 pathway
Ginkgolide B attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through disrupting NCOA4-FTH1 interaction
The role and molecular mechanism of Trametes Robiniophila Murr(Huaier) in tumor therapy
Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway
Unlocking the potential of Traditional Chinese Medicine (TCM)
The therapeutic effect of wasp venom (Vespa magnifica, Smith) and its effective part on rheumatoid arthritis fibroblast-like synoviocytes through modulating inflammation, redox homeostasis and ferroptosis
The extract from Quzhou Aurantii Fructus attenuates cough variant asthma through inhibiting the TRPV1/Ca2+/NFAT/TSLP pathway and ferroptosis via TRPV1 mediation in ovalbumin-induced mice
Inhibition of ferroptosis
Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease
Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway
Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury
Exploring the inhibitory effects of Guben Antai Decoction on oxidative stress damage and ferroptosis via the Nrf2/HO-1 pathway
Ferroptosis pathways
Solanum torvum induces ferroptosis to suppress hepatocellular carcinoma
Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K/AKT/Nrf2 pathway
Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling
Red clover (Trifolium pratense L.) extract inhibits ferroptotic cell death by modulating cellular iron homeostasis
Jianpi Huayu Jiedu Decoction prevents the progression of H. pylori and MNU-induced gastric precancerous lesions by inhibiting ferroptosis and remodeling linoleic acid metabolism
Sanqi qushi formula ameliorates podocyte injury in membranous nephropathy by inhibiting endoplasmic reticulum stress-induced ferroptosis
Gigantol
| Unique citing works | 59 |
|---|---|
| Citations per year | 14,75 |
| Citation span | 2022 - 2026 (5) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 59 |