Taraxacum mongolicum extract inhibited malignant phenotype of triple-negative breast cancer cells in tumor-associated macrophages microenvironment through suppressing IL-10 / STAT3 / PD-L1 signaling pathways
Bibliographic Data
| ID | 14738007 |
|---|---|
| Authors | Xin-Xin Deng, Xinxin Deng (Peking University Cancer Hospital), Yanna Jiao (Peking University Cancer Hospital), Yan-Na Jiao, Huifeng Hao (0000-0003-3396-1759, Peking University), Hui-Feng Hao, Dong Xue (0000-0002-2660-8589, Peking University Cancer Hospital, corresponding author), Changcai Bai (0000-0001-8321-559X, Ningxia Medical University, corresponding author), Chang-Cai Bai, Shu-Yan Han, Shuyan Han (0000-0001-6544-8090, Peking University, corresponding author) |
| Year | 2021 |
| Volume | 274 |
| Pages | 113978 |
| Publication date | 2021-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2021.113978 |
| PMID | 33716082 |
| OpenAlex | W3135404917 |
| Language | EN |
| Citations received | 3 |
| References cited | 39 |
Dandelion extract inhibited the proliferation, migration and invasion of TNBC cells in TAMs microenvironment through suppressing IL-10/STAT3/PD-L1 immunosuppressive signaling pathway. Furthermore, dandelion extract promoted the polarization of macrophages from M2 to M1 phenotype. Thus, our results indicated that dandelion may serve as a promising therapeutic strategy for TNBC by modulating tumor immune microenvironment
Biology · Breast cancer · Cancer · Cell growth · Dandelion · Immune system · MTT assay · Pathology · Traditional Chinese medicine · Triple-negative breast cancer · Tumor microenvironment · Cancer Cells and Metastasis · Chemistry · Cytokine Signaling Pathways and Interactions · Immune cells in cancer · Medicine · Biochemistry · Cancer Research · Immunology · Internal Medicine
Dandelion extract suppresses the stem-like properties of triple-negative breast cancer cells by regulating Cuedc2/β-catenin/OCT4 signaling axis
Taraxacum mongolicum Hand.-Mazz. extract disrupts the interaction between triple-negative breast cancer cells and tumor-associated macrophages by inhibiting RAC2/NF-κB p65/p38 Mapk pathway
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway
Whole Genome Transcriptome Analysis of the Association between Obesity and Triple-Negative Breast Cancer in Caucasian Women
Taraxacum mongolicum protects against Staphylococcus aureus-infected mastitis by exerting anti-inflammatory role via TLR2-NF-κB/Mapks pathways in mice
Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells
| Unique citing works | 3 |
|---|---|
| Citations per year | 1,5 |
| Citation span | 2024 - 2025 (2) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |