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Acorus tatarinowii Schott attenuates Alzheimer's disease via neuronal ferroptosis inhibition

A synergistic network pharmacology and multi-omics profiling study

Bibliographic Data

ID14738566
AuthorsRui Xiong (0000-0003-4608-7597, Army Medical University), Hengxu Liu (0000-0002-5088-9659, Army Medical University), Shipeng Zhang (0000-0003-4818-3275, Army Medical University), Lu Wang (0000-0002-9250-3988, Army Medical University), Pan Zhang (0000-0001-9080-9572, Army Medical University), Yiling Wang (0000-0001-8924-2417, PLA Army Service Academy), Xianhong Ou (0000-0002-3143-697X, Southwest Medical University, corresponding author), An-Guo Wu (0000-0002-9850-7576, Southwest Medical University, corresponding author), Anguo Wu (0000-0003-4688-6081), Xiaodan Lai (0000-0001-8368-8039, Army Medical University, corresponding author)
Year2026
Volume356
Pages120829
Publication date2026-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120829
PMID41167569
OpenAlexW4415641257
LanguageEN
Citations received2
References cited34

Disease · Metabolism · NFKB1 · Oxidative stress · Profiling (computer programming · Systems pharmacology · Alzheimer's disease research and treatments · Ferroptosis and cancer prognosis · Medicinal Plants and Neuroprotection

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    Open Access•Shuping Wang, Yuyan Guo et al.•Journal of Ethnopharmacology•2026

  • Acori tatarinowii Rhizoma-Curcumae Radix herbal pair ameliorates cognitive impairment and suppresses neuro-inflammation via Ca2+/CaMKKβ/AMPK/mTOR pathway in Alzheimer's disease

    Open Access•Chunlai Wang, Xiao Xu et al.•Journal of Ethnopharmacology•2026

  • Ferroptosis

    Open Access•Scott J Dixon, Kathryn M Lemberg et al.•Cell•2012

  • The GeneCards Suite

    Open Access•Gil Stelzer, Naomi Rosen et al.•Current Protocols in Bioinformatics•2016

  • David

    Open Access•Brad T Sherman, Ming Hao et al.•Nucleic Acids Research•2022

  • The STRING database in 2023

    Open Access•Damian Szklarczyk, Rebecca Kirsch et al.•Nucleic Acids Research•2023

  • Alzheimer's disease

    Open Access•Philip Scheltens, Bart De Strooper et al.•The Lancet•2021

  • Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway

    Open Access•Rui Xiong, Xiu-Ling Wang et al.•Journal of Ethnopharmacology•2020

  • Acori Tatarinowii Rhizoma regulates OCT3/Oatp2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer's disease

    Open Access•Junying Li, Xiaoxiao Shan et al.•Journal of Ethnopharmacology•2025

  • Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro

    Open Access•Chenchen Yan, Song Yang et al.•Journal of Ethnopharmacology•2024

  • Lignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels

    Open Access•Xin Meng, Wei Zhao et al.•Journal of Ethnopharmacology•2025

  • Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice

    Open Access•Sulei Wang, Jing Huang et al.•Journal of Ethnopharmacology•2024

  • Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway

    Open Access•Liangliang Kong, Yan Liu et al.•Journal of Ethnopharmacology•2024

  • Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway

    Open Access•Yi Yu, Jingwei Liang et al.•Journal of Ethnopharmacology•2024

Unique citing works2
Citations per year2
Citation span2026 - 2026 (1)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 2

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