Acorus tatarinowii Schott attenuates Alzheimer's disease via neuronal ferroptosis inhibition
A synergistic network pharmacology and multi-omics profiling study
Bibliographic Data
| ID | 14738566 |
|---|---|
| Authors | Rui Xiong (0000-0003-4608-7597, Army Medical University), Hengxu Liu (0000-0002-5088-9659, Army Medical University), Shipeng Zhang (0000-0003-4818-3275, Army Medical University), Lu Wang (0000-0002-9250-3988, Army Medical University), Pan Zhang (0000-0001-9080-9572, Army Medical University), Yiling Wang (0000-0001-8924-2417, PLA Army Service Academy), Xianhong Ou (0000-0002-3143-697X, Southwest Medical University, corresponding author), An-Guo Wu (0000-0002-9850-7576, Southwest Medical University, corresponding author), Anguo Wu (0000-0003-4688-6081), Xiaodan Lai (0000-0001-8368-8039, Army Medical University, corresponding author) |
| Year | 2026 |
| Volume | 356 |
| Pages | 120829 |
| Publication date | 2026-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120829 |
| PMID | 41167569 |
| OpenAlex | W4415641257 |
| Language | EN |
| Citations received | 2 |
| References cited | 34 |
Disease · Metabolism · NFKB1 · Oxidative stress · Profiling (computer programming · Systems pharmacology · Alzheimer's disease research and treatments · Ferroptosis and cancer prognosis · Medicinal Plants and Neuroprotection
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Acori tatarinowii Rhizoma-Curcumae Radix herbal pair ameliorates cognitive impairment and suppresses neuro-inflammation via Ca2+/CaMKKβ/AMPK/mTOR pathway in Alzheimer's disease
Ferroptosis
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Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway
Acori Tatarinowii Rhizoma regulates OCT3/Oatp2 and P-gp/MRP1 to “guide medicines upwards” in Kai-Xin-San to treat Alzheimer's disease
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro
Lignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels
Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway
| Unique citing works | 2 |
|---|---|
| Citations per year | 2 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 2 |