Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice

Bibliographic Data

ID14739013
AuthorsQiuhong Wang (0000-0002-4852-8723, Chinese Academy of Medical Sciences & Peking Union Medical College), Changfu Wang (0000-0002-6819-9672, Heilongjiang University of Chinese Medicine), ZunPeng Shu (0000-0001-6203-0617, Heilongjiang University of Chinese Medicine), Kelvin Chan (0000-0002-5738-9630, The University of Sydney), Shuming Huang, Shu-Ming Huang (0000-0002-2161-9801, Chinese Academy of Medical Sciences & Peking Union Medical College), Yan Li (0000-0001-6650-7726, Heilongjiang University of Chinese Medicine), Yang Xiao (0000-0001-9237-8913, Heilongjiang University of Chinese Medicine), Lihua Wu (0000-0003-2797-3833, Heilongjiang University of Chinese Medicine), Haixue Kuang (0000-0001-9136-8414, Heilongjiang University of Chinese Medicine, corresponding author), Xiaobo Sun (0000-0003-0938-412X, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author)
Year2014
Volume153
Issue2
Pages318-325
Publication date2014-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2013.11.017
PMID24269774
OpenAlexW1994602539
LanguageEN
Citations received1
References cited35

These findings suggest that AD-EFV could ameliorate Aβ induced cognitive dysfunction through two underlying mechanisms: AD-EFV enhances the cerebral cholinergic function by increasing the secretion of ACh and enhancing the ChAT activity, and AD-EFV protects the brain neurons from Aβ induced apoptosis via activating the p-ERK and Bcl-2 signaling and suppressing the Bax pathways. Besides, the main constituents of AD-EFV are lignans which might be responsible for the AD-activity of Valeriana amurensis

Apoptosis · BETA (programming language · Biology · Cholinergic · Cholinergic neuron · Cognition · Attention Deficit Hyperactivity Disorder · Computer Science · Medicinal Plant Extracts Effects · Medicine · Neuroscience · Tryptophan and brain disorders · Biochemistry · Pharmacology

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