Xiaoai Jiedu recipe reduces cell survival and induces apoptosis in hepatocellular carcinoma by stimulating autophagy via the AKT/mTOR pathway
Bibliographic Data
| ID | 14739839 |
|---|---|
| Authors | YI JI (0000-0002-5125-1163), Ji Yi (0000-0001-6583-7192, Nanjing University of Chinese Medicine), Li Li (0000-0001-9700-9682, Nanjing University of Chinese Medicine), Wen-Ting Li (0000-0001-5288-8310, Nanjing University of Chinese Medicine), Wenting Li (0000-0002-0821-7066), Liu Li (0009-0000-7928-8614, Nanjing University of Chinese Medicine), Yanxia Ma (0000-0003-3836-3889, Nanjing University of Chinese Medicine), Qingfeng Li (0000-0002-6390-6921, Nanjing University of Chinese Medicine), Xi Chen (0000-0002-2058-0351, Nanjing University of Chinese Medicine), Wenyue Zhao (Nanjing University of Chinese Medicine), Hengzhou Zhu (0009-0008-0142-0759, Nanjing University of Chinese Medicine, corresponding author), Jiege Huo (0000-0002-0463-134X, Nanjing University of Chinese Medicine, corresponding author), Mianhua Wu (0000-0001-7626-6874, Nanjing University of Chinese Medicine, corresponding author) |
| Year | 2025 |
| Volume | 339 |
| Pages | 119135 |
| Publication date | 2025-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.119135 |
| PMID | 39586558 |
| OpenAlex | W4404641783 |
| Language | EN |
| References cited | 47 |
These studies show that XJR activates autophagy in both cellular and animal models to induce apoptosis and decrease HCC cell proliferation, as shown by network pharmacology and verification assays. Further, these findings provide experimental evidence that the anti-tumor activity of XJR involves autophagy stimulation
Apoptosis · Autophagy · Biology · Cell growth · Cell survival · Hepatocellular carcinoma · PI3K/AKT/mTOR pathway · Protein kinase B · Traditional medicine · Autophagy in Disease and Therapy · Ginseng Biological Effects and Applications · Medicine · Sirtuins and Resveratrol in Medicine · Biochemistry · Cancer Research
| Citation velocity | historical |
|---|---|
| Highly cited | No |