Reduning injection and its effective constituent luteoloside protect against sepsis partly via inhibition of HMGB1/TLR4/NF-κB/Mapks signaling pathways

Bibliographic Data

ID14743227
AuthorsZheng Wang (0000-0003-0758-2202, Zhejiang University), Wen Chen (0000-0002-6839-8890, Zhejiang University), Yunying Li (0000-0002-0424-0154, Tianjin University of Traditional Chinese Medicine), Shuying Zhang (0000-0001-9412-8459, Tianjin University of Traditional Chinese Medicine), He Lou (0000-0002-9235-5700, Zhejiang University), Xiaoyan Lu (0000-0001-5710-4968, Zhejiang University, corresponding author), Xiaohui Fan (0009-0008-7138-9865, Tianjin University of Traditional Chinese Medicine, corresponding author)
Year2021
Volume270
Pages113783
Publication date2021-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2021.113783
PMID33421596
OpenAlexW3120873612
LanguageEN
Citations received1
References cited40

RDN and its effective constituent luteoloside exhibited a significant protective effect against sepsis, which were potential candidate drugs for treatment of sepsis. The mechanism of antisepsis partly was related to inhibition of HMGB1/TLR4/NF-κB/MAPKs signaling pathways. The results provide an evidence base for the follow-up clinical application of RDN in treatment of sepsis

Biology · Ex vivo · Gardenia jasminoides · In vivo · Inflammation · Lipopolysaccharide · Pathology · Sepsis · TLR4 · Advanced Glycation End Products research · Immune Response and Inflammation · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Immunology · Pharmacology

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