Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway
Bibliographic Data
| ID | 14747009 |
|---|---|
| Authors | Dengyun Nie (0000-0001-6622-7513, Nanjing University of Chinese Medicine), Yakun Zhang (0000-0001-6622-5016, Nanjing University of Chinese Medicine), Rong Jia (0000-0002-5306-5241, Nanjing University of Chinese Medicine), Zhe Fang (0000-0003-0864-3644, Nanjing University of Chinese Medicine), Guisong Zhu (0000-0003-2036-7531, Nanjing University of Chinese Medicine), Biao Xu (0000-0001-8695-7396, Nanjing University of Chinese Medicine), Ting Guo (0000-0001-7537-2464, Nantong University, corresponding author), Han Chao Zhang (Nanjing University of Chinese Medicine, corresponding author), Han Zhang (0000-0002-5265-7659, Nanjing University of Chinese Medicine, corresponding author) |
| Year | 2026 |
| Volume | 364 |
| Pages | 121500 |
| Publication date | 2026-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2026.121500 |
| PMID | 41796614 |
| OpenAlex | W7134112581 |
| Language | EN |
| References cited | 25 |
Cachexia · Cancer · Cancer cachexia · Cell culture · Decoction · In vitro · Macrophage polarization · Antioxidants, Aging, Portulaca oleracea · Immune cells in cancer · Nutrition and Health in Aging
Oligosaccharides and small molecule components of Sijunzi decoction modulate the gut microbiota-bile acid axis to synergistically alleviate spleen deficiency syndrome
Modified Sijunzi decoction can alleviate cisplatin-induced toxicity and prolong the survival time of cachectic mice by recovering muscle atrophy
A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model
Sijunzi decoction enhances sensitivity of colon cancer cells to NK cell destruction by modulating P53 expression
Sijunzi decoction improves lipid metabolism via regulation of Wnt/β-catenin signaling pathway in diabetic mice and 3T3-L1 cells
| Citation velocity | historical |
|---|---|
| Highly cited | No |