Enhanced severity of secondary dengue-2 infections

Death rates in 1981 and 1997 Cuban outbreaks

Bibliographic Data

ID14965675
AuthorsMaria G Guzmán (0000-0001-6161-9489, corresponding author), Gustavo Kourí (Instituto de Medicina Tropical “Pedro Kourí”), Luís Valdés (0000-0003-2540-8013), José Bravo (0009-0007-2593-8846, Instituto de Medicina Tropical “Pedro Kourí”), Santiago Vazquez (0000-0002-2707-1031, Instituto de Medicina Tropical “Pedro Kourí”), Susana Vazquez (0000-0002-8367-7513), Scott B Halstead (0000-0002-7818-348X, Johns Hopkins University)
Year2002
Volume11
Issue4
Pages223-227
Publication date2002-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueRevista Panamericana de Salud Pública (JOURNAL)
Journal identifiersISSN: 1020-4989 • E-ISSN: 1680-5348
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s1020-49892002000400003
PMID12049030
OpenAlexW2111222009
SCIELO_PIDS1020-49892002000400003
LanguageEN
Citations received4
References cited13

We found a marked increase in severity with the longer of the two intervals (20 years) between an initial DEN-1 infection and a secondary DEN-2 infection. Such a difference may be due to subtle shifts in causative dengue strains or to changes with the passage of time in the circulating population of human dengue antibodies. These observations have important implications for dengue control, pathogenic mechanisms, and vaccine development

Case fatality rate · Dengue fever · Dengue virus · Geography · Mortality rate · Outbreak · Serotype · Demography · Medicine · Mosquito-borne diseases and control · Vibrio bacteria research studies · Viral Infections and Vectors · Epidemiology · Internal Medicine · Pediatrics · Virology

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