Body shape trajectories and risk of breast cancer
Results from the SUN (‘Seguimiento Universidad De Navarra’) Project
Bibliographic Data
| ID | 15090398 |
|---|---|
| Authors | Rodrigo Sánchez-Bayona (0000-0002-5255-6620, Hospital Universitario 12 De Octubre), Carmen Sayón-Orea (0000-0002-4137-3263, Universidad de Navarra), Itziar Gardeazabal (0000-0003-2730-4998, Universidad de Navarra), Javier Llorca (0000-0001-8569-861X, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alfredo Gea (0000-0002-2229-4690, Navarre Institute of Health Research), Marta Santisteban (0000-0003-0625-686X, Clinica Universidad de Navarra), José M Martín-Moreno (0000-0002-8648-5541, Universitat de València), Estefanía Toledo (0000-0002-6263-4434, Centro de Investigación Biomédica en Red, corresponding author) |
| Year | 2021 |
| Volume | 24 |
| Issue | 3 |
| Pages | 467-475 |
| Publication date | 2021-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980020004322 |
| PMID | 33168117 |
| OpenAlex | W3098886655 |
| Language | EN |
| References cited | 33 |
Objective: The aim of this study was to assess body shape trajectories in childhood and midlife in relation to subsequent risk of breast cancer (BC) in a Mediterranean cohort. Design: The ‘Seguimiento Universidad de Navarra’ (SUN) Project is a dynamic prospective cohort study of university graduates initiated in 1999. With a group-based modelling approach, we assessed body shape trajectories from age 5 to 40 years. Multivariable Cox regression models were used to estimate the hazard ratio (HR) for BC after the age of 40 years according to the body shape trajectory. Setting: City of Pamplona, in the North of Spain. Participants: 6498 women with a mean age of 40 years ( sd 9). Results: We identified four distinct body shape trajectories (‘childhood lean-midlife increase’ (19·9 %), ‘childhood medium-midlife stable’ (53 %), ‘childhood heavy-midlife stable’ (21 %) and ‘childhood heavy-midlife increase’ (6·1 %)). Among 54 978 women-years of follow-up, we confirmed eighty-two incident cases of BC. Women in the ‘childhood lean-midlife increase’ group showed a higher risk of BC (HR = 1·84, 95 % CI 1·11, 3·04) compared with women in the ‘childhood medium-midlife stable’ category. This association was stronger for postmenopausal BC (HR = 2·42, 95 % CI 1·07, 5·48). Conclusions: Our results suggest a role for lifetime adiposity in breast carcinogenesis
Breast cancer · Cancer · Cohort · Cohort study · Confidence interval · Hazard ratio · Proportional hazards model · Prospective cohort study · Cancer Risks and Factors · Demography · Medicine · Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Gerontology · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |