Serum folate and vitamin B12 status in young Brazilian children
Bibliographic Data
| ID | 15090681 |
|---|---|
| Authors | Lara LS Silva (Universidade de São Paulo), Wafaie W Fawzi (0000-0002-2908-600X, Harvard Global Health Institute), Marly Augusto Cardoso (0000-0003-0973-3908, Universidade de São Paulo, corresponding author) |
| Year | 2019 |
| Volume | 22 |
| Issue | 7 |
| Pages | 1-9 |
| Publication date | 2019-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980019000193 |
| PMID | 30819263 |
| OpenAlex | W2918237289 |
| Language | EN |
| References cited | 25 |
Objective To assess the nutritional status of folate and vitamin B 12 with anaemia in young children. Design A cross-sectional study was conducted at the primary health-care centres of four Brazilian cities. Folate and vitamin B 12 were assessed by fluoroimmunoassay. Multilevel Poisson regression models were used to explore the association of folate and vitamin B 12 status in relation to anaemia in young children. Setting Brazil. Participants Children ( n 460) aged 11 to 15 months. Results The median (interquartile range) of serum folate was 39·7 (28·8–55·3) nmol/l and only four children presented with folate deficiency (<10 nmol/l). Surprisingly, 30·9 % of children presented with serum folate concentrations above the upper limit of detectable values by the commercial kit used for analysis. The frequency of vitamin B 12 deficiency (<148 pmol/l) was 15 % and it was inversely associated with the highest tertile of serum folate concentrations ( P <0·001). Having high serum folate concentration (≥50·1 nmol/l) and vitamin B 12 ≥148 pmol/l was associated with lower frequency of anaemia in these children (prevalence ratio=0·53; 95% CI 0·30, 0·92). Conclusions High frequency of elevated serum concentration of folate was found among young Brazilian children and 15 % of them had vitamin B 12 deficiency. The combination of high serum folate and normal vitamin B 12 status was associated with a lower frequency of anaemia in these children. Improvements in the current strategies to promote healthy food-based complementary feeding along with prevention and control of micronutrient deficiencies are recommended to improve children’s health
Anemia · Cross-sectional study · Environmental health · Interquartile range · Micronutrient · Poisson regression · Population · Vitamin · Vitamin b · Vitamin B12 · Child Nutrition and Water Access · Folate and B Vitamins Research · Iron Metabolism and Disorders · Medicine · Internal Medicine · Physiology
| Highly cited | No |
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