Genetic and environmental factors associated with vitamin B 12 status in Amazonian children
Bibliographic Data
| ID | 15092928 |
|---|---|
| Authors | Fernanda Cobayashi (0000-0001-7890-3363, Universidade de São Paulo), Luciana Y Tomita (0000-0002-9652-038X, Universidade Federal de São Paulo), Rosangela Aparecida Augusto (Universidade de São Paulo), Vania D’Almeida (0000-0003-0947-5312, Universidade Federal de São Paulo), Marly Augusto Cardoso (0000-0003-0973-3908, Universidade de São Paulo, corresponding author) |
| Year | 2015 |
| Volume | 18 |
| Issue | 12 |
| Pages | 2202-2210 |
| Publication date | 2015-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980014003061 |
| PMID | 25591618 |
| OpenAlex | W2156320501 |
| Language | EN |
| Citations received | 1 |
| References cited | 49 |
Objective To evaluate the prevalence of vitamin B 12 deficiency and factors associated with vitamin B 12 status in Amazonian children. Design Genetic risk score (GRS), socio-economic and nutritional status, and morbidity data were the independent variables used in multiple linear regression models to evaluate factors associated with vitamin B 12 status in a population-based cross-sectional study. GRS was created by summing a number of known risk alleles for low serum vitamin B 12 . Setting Acrelândia, western Brazilian Amazon. Subjects Children ( n 988) aged Results Overall prevalence of vitamin B 12 deficiency ( β =0·017, P= 0·030) and animal protein intake (β =0·219, P= 0·003) were positively associated with vitamin B 12 status. GRS ( β =−0·114, P β =–0·049, P 12 status was positively associated with wealth index ( β =0·012, P Z -score ( β =0·024 , P= 0·033) and serum vitamin A ( β =0·089, P 0·001). Age≥60 months (β =–0·118, P 0·001), GRS ( β =–0·048 , P 0·001), maternal schooling β =–0·083, P 0·001), low intake of animal-derived foods ( β =–0·050, P= 0·030), serum homocysteine ( β =–0 · 053, P 0·001), serum folate ≥23·6 nmol/l ( β =–0·055, P= 0·012) and geohelminth infection ( β =–0·141, P= 0·017) were negatively associated with vitamin B 12 status. Conclusions GRS, poverty, low intake of animal-derived foods, geohelminth infection, vitamin A and folate status were important factors associated with vitamin B 12 status of children in our study
Cross-sectional study · Environmental health · Homocysteine · Population · Vitamin B12 · Vitamin D and neurology · Child Nutrition and Water Access · Folate and B Vitamins Research · Iron Metabolism and Disorders · Medicine · Internal Medicine
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| Citations per year | 0.14 |
|---|---|
| Citation span | 2019 - 2019 (1) |
| Highly cited | No |