Evaluation of iodine nutritional status during pregnancy by estimated 24-h urinary iodine excretion

Population variation range and individual accuracy

Bibliographic Data

ID15091013
AuthorsYe Bu (Harbin Medical University), Yan Cai (0000-0003-0888-7526, Harbin Medical University), Chunlei Ji (0000-0002-7425-0681, Harbin Medical University), Chunyan Zhao (0000-0003-4163-1848, Harbin Medical University), Chunyuan Tian (Harbin Medical University), Bo Pang (0000-0002-6411-8628), Mengqi Shi (0009-0005-4923-2421), Xin Li (0000-0002-3425-8566, Harbin Medical University), Ying Liu (0000-0001-5584-7805, Harbin Medical University, corresponding author), Dianjun Sun (0000-0003-1701-4305, Harbin Medical University, corresponding author)
Year2021
Volume25
Issue2
Pages1-11
Publication date2021-08-12
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980021003335
PMID34380579
OpenAlexW3190434664
LanguageEN
References cited32

Objective: To explore the accuracy of estimated 24-h urinary iodine excretion (24-h UIE est ) in assessing iodine nutritional status. Design: Fasting venous blood, 24-h and spot urine samples were collected during the day. The urinary iodine concentration (UIC) and urinary creatinine concentration (UCrC) were measured, and the urinary iodine-to-creatinine ratio (UI/Cr), 24-h UIE est , and 24-h urinary iodine excretion (24-h UIE) were calculated. At the population level, correlation and consistency between UIC, UI/Cr, 24-h UIE est and 24-h UIE were assessed using correlation analysis and Bland–Altman plots. At the individual level, receiver operating characteristic (ROC) curves were used to analyse the accuracy of the above indicators for evaluating insufficient and excessive iodine intake. The reference interval of 24-h UIE est was established based on percentile values. Setting: Indicator can accurately evaluate individual iodine nutrition during pregnancy remains controversial. Participants: Pregnant women ( n 788). Results: Using 24-h UIE as standard, the correlation coefficients of 24-h UIE est from different periods of the day ranged from 0·409 to 0·531, and the relative average differences ranged from 4·4 % to 10·9 %. For diagnosis of insufficient iodine intake, the area under the ROC curve of 24-h UIE est was 0·754, sensitivity and specificity were 79·6 % and 65·4 %, respectively. For diagnosis of excessive iodine intake, the area of 24-h UIE est was 0·771, sensitivity and specificity were 66·7 % and 82·0 %, respectively. The reference interval of 24-h UIE est was 58·43–597·65 μg. Conclusions: Twenty-four-hour UIE est can better indicate iodine nutritional status at a relatively large sample size in a given population of pregnant women. It can be used for early screening at the individual level to obtain more lead time for pregnant women

Iodine · Iodine deficiency · Population · Pregnancy · Urinary system · Variation (astronomy · Thyroid Cancer Diagnosis and Treatment · Thyroid Disorders and Treatments · Vitamin D Research Studies

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