Habitual high phosphorus intakes and foods with phosphate additives negatively affect serum parathyroid hormone concentration
A cross-sectional study on healthy premenopausal women
Bibliographic Data
| ID | 15091968 |
|---|---|
| Authors | Virpi E Kemi, Virpi Kemi (University of Helsinki), Hannu Rita (University of Helsinki), Hannu J Rita, Merja UM Kärkkäinen, Merja Kärkkäinen (University of Helsinki), Heli T Viljakainen (0000-0002-7486-3437, University of Helsinki), Marika M Laaksonen, Marika Laaksonen (University of Helsinki), Terhi A Outila (University of Helsinki), Christel Lamberg-Allardt (0000-0001-7326-1904, University of Helsinki, corresponding author), Christel JE Lamberg-Allardt |
| Year | 2009 |
| Volume | 12 |
| Issue | 10 |
| Pages | 1885-1892 |
| Publication date | 2009-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980009004819 |
| PMID | 19216809 |
| OpenAlex | W2151568907 |
| Language | EN |
| Citations received | 1 |
| References cited | 35 |
Objective Foods can contain natural phosphorus (NP) and phosphate-containing food additives (AP). The main objective of the present study was to investigate whether NP and AP of habitual diets differ in their effects on markers of Ca metabolism. We also investigated the impact of total habitual dietary P intake on markers of Ca metabolism. Design Cross-sectional study. Fasting blood samples were collected and participants kept a 4 d food record, from which dietary intake of total P and the consumption of NP (milk and cheese, excluding processed cheese) and AP (processed cheese) sources were calculated. Participants were divided into groups according to their NP- and AP-containing food consumption and into quartiles according to their total P intake. Setting Southern Finland. Subjects One hundred and forty-seven healthy premenopausal women aged 31–43 years. Results Relative to the lowest total dietary P quartile, mean serum parathyroid hormone (S-PTH) concentration was higher ( P = 0·048, analysis of covariance (ANCOVA)) and the mean serum ionized Ca concentration lower ( P = 0·016, ANCOVA) in the highest P intake quartile. Mean S-PTH concentrations were higher among participants who consumed processed cheese ( P = 0·027, ANCOVA) and less milk and other cheese than processed cheese ( P = 0·030, ANCOVA). Conclusions High total habitual dietary P intake affected S-PTH unfavourably. Furthermore, phosphate additives may have more harmful effects on bone than other P sources, as indicated by higher mean S-PTH concentration among participants who consumed AP-containing foods. Because of the high dietary P intake and current upward trend in consumption of processed foods in Western countries, these findings may have important public health implications
Animal science · Biology · Calcium · Confidence interval · Parathyroid hormone · Phosphate · Phosphorus · Quartile · Chemistry · Folate and B Vitamins Research · Genetic Syndromes and Imprinting · Medicine · Parathyroid Disorders and Treatments · Biochemistry · Endocrinology · Food Science · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,07 |
| Citation span | 2011 - 2011 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |