Aflatoxin exposure was not associated with childhood stunting
Results from a birth cohort study in a resource-poor setting of Dhaka, Bangladesh
Bibliographic Data
Objective: Chronic aflatoxin exposure has been associated with childhood stunting (length-for-age/height-for-age sd ), while data lacks for Bangladesh, a country with substantial burden of childhood stunting. This paper examined the association between aflatoxin exposure and childhood stunting in a slum setting of Dhaka city. Design: In this MAL-ED aflatoxin birth cohort study, plasma samples were assayed for aflatoxin B1-lysine adduct (AFB1-lys) by MS at 7, 15, 24 and 36 months of age for 208, 196, 173 and 167 children to assess chronic aflatoxin exposure. Relationship between aflatoxin exposure and anthropometric measures was examined by mixed-effects logistic regression models. Setting and participants: The study was conducted in Mirpur, Dhaka, where children were followed from birth to 36 months. Results: Prevalence of stunting increased from 21 % at 7 months to 49 % at 36 months of age. Mean AFB1-lys concentrations at 7, 15, 24 and 36 months were 1·30 (range 0·09–5·79), 1·52 (range 0·06–6·35), 3·43 (range 0·15–65·60) and 3·70 (range 0·09–126·54) pg/mg albumin, respectively, and the percentage of children with detectable AFB1-lys was 10, 21, 18 and 62 %, respectively. No association was observed between aflatoxin exposure and stunting in multivariable analyses. Factors associated with childhood stunting were age, low birth weight, maternal height, stool myeloperoxidase and number of people sleeping in one room. Conclusions: A relatively lower exposure to aflatoxin may not influence the linear growth of children. This finding indicates a threshold level of exposure for linear growth deficit and further investigation in other areas where higher concentrations of aflatoxin exposure exist
Aflatoxin · Anthropometry · Biology · Cohort · Environmental health · Logistic regression · Air Quality and Health Impacts · Child Nutrition and Water Access · Medicine · Nutritional Studies and Diet · Food Science · Internal Medicine · Pediatrics · Toxicology
Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Kenya
Weight Gain in the First Two Years of Life Is an Important Predictor of Schooling Outcomes in Pooled Analyses from Five Birth Cohorts from Low- and Middle-Income Countries
WHO Child Growth Standards based on length/height, weight and age
Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Bangladesh
Risk factors of stunting among children living in an urban slum of Bangladesh
Childhood stunting
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |