Oxidative stress during early pregnancy and birth outcomes
Bibliographic Data
| ID | 15093455 |
|---|---|
| Authors | Lisha Shastri (0000-0002-7976-0429, St.John's Medical College Hospital), Rajkumar S Pammal (0000-0001-5879-2870, Harvard College Observatory), Indu Mani (0000-0001-6912-6363, St. John's National Academy of Health Sciences), Tinku Thomas (0000-0002-1786-6076, St. John's National Academy of Health Sciences), Anura V Kurpad (0000-0001-7998-2438, St. John's National Academy of Health Sciences, corresponding author) |
| Year | 2016 |
| Volume | 19 |
| Issue | 17 |
| Pages | 3210-3215 |
| Publication date | 2016-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980016001191 |
| PMID | 27253267 |
| OpenAlex | W2413429722 |
| Language | EN |
| References cited | 22 |
Objective Routine high-dose Fe supplementation in non-anaemic pregnant women may induce oxidative stress and eventually affect birth outcomes. The aim of the present study was to measure oxidative stress markers in pregnant women with low/normal and high Hb values in trimester 1 (Hb 1 ) and to relate these to birth weight. Design A cross-sectional study where selected oxidative stress markers were analysed in both maternal (trimester 1; T1) and cord blood samples and correlated with birth weight. Setting A tertiary hospital in urban South India. Subjects One hundred women were chosen based on their Hb 1 values (forty women with low/normal Hb 1 ( 1 (≥120 g/l)). Results In T1, women with high Hb 1 values were found to have lower paraoxonase-1 (PON-1) activity (424·7 ( sd 163·7) v . 532·9 ( sd 144·7) pmol p -nitrophenol formed/min per ml plasma, P =0·002) and higher lipid peroxides compared with women with low/normal Hb 1 . Routine supplementation of Fe to these women resulted in persistent lower PON-1 activity in cord blood ( P =0·02) and directionally lower ( P =0·142) birth weights. Furthermore, women with high Hb 1 who delivered low-birth-weight babies were observed to have lowest PON-1 activity in T1. No changes were observed in other markers (myeloperoxidase activity and total antioxidant levels). Conclusions Routine Fe supplementation in pregnant women with high Hb 1 associated with increased oxidative stress, as reflected by low PON-1 activity in T1, could potentially lead to deleterious effects on birth weight
Aryldialkylphosphatase · Biology · Birth weight · Cord blood · Obstetrics · Oxidative stress · Paraoxonase · Pregnancy · Medicine · Paraoxonase enzyme and polymorphisms · Pregnancy and preeclampsia studies · Pregnancy-related medical research · Biochemistry · Internal Medicine · Physiology
| Citation velocity | historical |
|---|---|
| Highly cited | No |