Validation of a BMI cut-off point to predict an adverse cardiometabolic profile with adiposity measurements by dual-energy X-ray absorptiometry in Guatemalan children
Bibliographic Data
Objective To identify a body fat percentage (%BF) threshold related to an adverse cardiometabolic profile and its surrogate BMI cut-off point. Design Cross-sectional study. Setting Two public schools in poor urban areas on the outskirts of Guatemala City. Subjects A convenience sample of ninety-three healthy, prepubertal, Ladino children (aged 7–12 years). Results Spearman correlations of cardiometabolic parameters were higher with %BF than with BMI-for-age Z -score. BMI-for-age Z -score and %BF were highly correlated ( r =0·84). The %BF threshold that maximized sensitivity and specificity for predicting an adverse cardiometabolic profile (elevated homeostasis model assessment–insulin resistance index and/or total cholesterol:HDL-cholesterol ratio) according to receiver operating characteristic curve analysis was 36 %. The BMI-for-age Z -score cut-off point that maximized the prediction of BF ≥ 36 % by the same procedure was 1·5. The area under the curve (AUC) for %BF and for BMI data showed excellent accuracy to predict an adverse cardiometabolic profile (AUC 0·93 ( sd 0·04)) and excess adiposity (AUC 0·95 ( sd 0·02)). Conclusions Since BMI standards have limitations in screening for adiposity, specific cut-off points based on ethnic-/sex- and age-specific %BF thresholds are needed to better predict an adverse cardiometabolic profile
Adverse effect · Area under the curve · Body mass index · Cholesterol · Cross-sectional study · Insulin resistance · Lipid Profile · Obesity · Receiver operating characteristic · Surrogate endpoint · Body Composition Measurement Techniques · Cardiovascular Disease and Adiposity · Demography · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine
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| Unique citing works | 1 |
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| Citation span | 2019 - 2019 (1) |
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| Citation types | Neutral: 1 |