Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals
A systematic review and meta-analysis
Bibliographic Data
| ID | 15096099 |
|---|---|
| Authors | Abigail R Bournot (0000-0003-2440-0167), Andrea L Darling (0000-0002-7038-3161), Ian D Givens, Julie A Lovegrove (0000-0001-7633-9455), Susan A Lanham-New (0000-0003-3153-6345), Kathryn H Hart |
| Year | 2024 |
| Volume | 27 |
| Issue | 1 |
| Publication date | 2024-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980024001861 |
| Language | EN |
| References cited | 48 |
Objective: This systematic review and meta-analysis examined the evidence for a potential relationship between vitamin D status and vitamin D supplementation on immune function biomarkers and prevention of acute respiratory tract infections (ARTI) in dark-skinned individuals. Design: Six databases were searched (inception to December 2021) for randomised controlled trials (RCT) and observational studies. A narrative synthesis and random-effects meta-analysis were used to synthesise the findings. Setting: Not applicable. Participants: Ethnic groups other than white, with or without a white comparator. Results: After duplicates were removed, 2077 articles were identified for screening. A total of eighteen studies ( n 36 707), including seven RCT and 11 observational studies, met the inclusion criteria, and three RCT ( n 5778) provided sufficient data of high enough quality to be included in a meta-analysis. An inverse association between vitamin D status and at least one inflammatory biomarker in black adults was found in three studies, and vitamin D status was inversely associated with ARTI incidence in black and Indigenous groups in two studies. There was no significant effect of vitamin D supplementation on differences in ARTI incidence in ethnic minority groups (OR, 1·40; 95 % CI: 0·70, 2·79; P = 0·34), nor African American (OR, 1·77; 95 % CI: 0·51, 6·19; P = 0·37) or Asian/Pacific (OR, 1·08; 95 % CI: 0·77, 2·68; P = 0·66) subgroups. Conclusions: There is a lack of conclusive evidence supporting an association between vitamin D status and immune function or ARTI incidence in dark-skinned individuals. Further RCT in diverse ethnic populations are urgently needed
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| Citation velocity | historical |
|---|---|
| Highly cited | No |