Dietary intake and the insulin-like growth factor system

Effects of migration in two related populations in India and Britain with markedly different dietary intake

Bibliographic Data

ID15096166
AuthorsAH Heald (Salford Royal Hospital, corresponding author), Ritika Sharma (0000-0003-3255-0747, Salford Royal Hospital), Runaaz Ali (0000-0002-9738-4092), Simon Anderson (0000-0002-4428-4290, University of Manchester), SG Anderson, Avni Vyas (0000-0002-7436-4996, University of Manchester), Kirk Siddals (0000-0002-4647-3140, University of Manchester), J Patel (0000-0003-0618-6750), Jyoti C Patel (0000-0003-0295-6180, University of Manchester), Deepak Bhatnagar (Manchester Royal Infirmary), D Prabharkaran (All India Institute of Medical Sciences), A Rudenski (University of Manchester), E Hughes (0000-0001-8294-1733, Sandwell General Hospital), PN Durrington (Manchester Royal Infirmary), Martin Gibson (0000-0002-1331-1524, Salford Royal Hospital), JM Gibson, J K Cruickshank (University of Manchester), JK Cruickshank
Year2005
Volume8
Issue6
Pages620-627
Publication date2005-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1079/phn2005729
PMID16236191
OpenAlexW2055749172
LanguageEN
Citations received6
References cited36

Background The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease. Objective We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate. Design, subjects and setting Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK ( n = 205) compared with people still resident in the same villages of origin in India ( n = 246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured. Results Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1–153.6) vs. 100.9 (94.6–107.3) ng ml -1 ; F = 76.6, P -1 ; F = 48.4, P ρ = 0.45, P ρ = 0.44, P P P ρ = -0.27, P P P = 0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose. Conclusion In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs

Biology · Growth factor · Insulin-like growth factor · Birth, Development, and Health · Growth Hormone and Insulin-like Growth Factors · Liver Disease Diagnosis and Treatment · Medicine · Internal Medicine

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