Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years
Bibliographic Data
| ID | 15097144 |
|---|---|
| Authors | Luanne Robalo DeChristopher (0000-0002-3540-0405, New York Medical College, corresponding author), Jaime Uribarri (0000-0001-9826-1134, Icahn School of Medicine at Mount Sinai), Kari L Tucker (0000-0001-7640-662X, University of Massachusetts Lowell) |
| Year | 2016 |
| Volume | 19 |
| Issue | 1 |
| Pages | 123-130 |
| Publication date | 2016-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980015000865 |
| PMID | 25857343 |
| OpenAlex | W2153758267 |
| Language | EN |
| Citations received | 5 |
| References cited | 30 |
Objective High soft drink consumption has been linked with asthma. Anecdotal evidence links high-fructose corn syrup with asthma. The receptor of advanced glycation end products (RAGE) has emerged as a mediator of asthma. The objectives of the present study were to: (i) assess the correlation between intake of beverages containing excess free fructose (EFF beverages) and asthma in children; and (ii) epidemiologically test the mechanistic hypothesis that intake of high EFF beverages, such as apple juice or beverages sweetened with high-fructose corn syrup, is associated with increased risk of asthma. This hypothesis is based on the possible effect of increases in the in situ intestinal formation of advanced glycation end products (enFruAGE) with EFF, which may be absorbed and play a role in RAGE-mediated asthma. Design We examined cross-sectional associations between beverage intake and self-reported current or history of asthma. Exposure variables were EFF beverages, including apple juice (AJ), non-diet soft drinks (ndSD) and fruit drinks (FD). Orange juice (OJ), not an EFF beverage, was included as a comparison. Rao–Scott χ 2 analysis was used for prevalence differences and logistic regression for associations, adjusted for age, sex, race/ethnicity, BMI and total energy intake. Setting Data are from the National Health and Nutrition Examination Survey 2003–2006, a nationally representative survey. Subjects US children ( n 1961) aged 2–9 years with complete responses on the dietary frequency questionnaire. Results Intakes of EFF beverages were significantly associated with asthma in 2–9-year-olds. Adjusted odds of asthma in children consuming EFF beverages ≥5 times/week was more than five times that in children consuming these beverages ≤1 time/month (OR=5·29, P =0·012). Children consuming AJ ≥5 times/week v . ≤1 time/month, adjusted for the other beverages, were more than twice as likely to have asthma (OR=2·43, P =0·035). In contrast, there was a tendency for OJ to be protective. Conclusions These results support the hypothesis that intake of high EFF beverages, including AJ and beverages sweetened with high-fructose corn syrup, is associated with asthma in children aged 2–9 years. Results support the mechanistic hypothesis that enFruAGE may be an overlooked contributor to asthma in children. Longitudinal studies are needed to provide evidence of causal association
Asthma · Biology · Environmental health · Fruit juice · Consumer Attitudes and Food Labeling · Diet, Metabolism, and Disease · Medicine · Nutritional Studies and Diet · Food Science · Internal Medicine
Clinical characteristics and associated factors of airway allergic diseases among children
The potential link between sugar-sweetened beverage consumption and post-exercise airway narrowing across puberty
Daily intake of soft drinks is associated with symptoms of anxiety and depression in Chinese adolescents
Soft drinks consumption and child behaviour problems
Disproportionately higher asthma risk and incidence with high fructose corn syrup, but not sucrose intake, among Black young adults
| Citations per year | 0.5 |
|---|---|
| Citation span | 2016 - 2026 (11) |
| Highly cited | No |