The importance of controlling for the acute-phase response in the population-based assessment of vitamin A status
A study in children of pre-school age in Uganda
Bibliographic Data
| ID | 15097154 |
|---|---|
| Authors | Rhona Baingana (0000-0002-9954-8257, Makerere University, corresponding author), Dennis Matovu-Kasozi (Makerere University), Dean Garrett (Program for Appropriate Technology in Health) |
| Year | 2013 |
| Volume | 16 |
| Issue | 9 |
| Pages | 1540-1547 |
| Publication date | 2013-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980012004351 |
| PMID | 23021569 |
| OpenAlex | W2072032786 |
| Language | EN |
| Citations received | 2 |
| References cited | 35 |
Objective To improve estimates of vitamin A deficiency in children of pre-school age in the 2006 Uganda Demographic and Health Survey (UDHS 2006). Design A cross-sectional study in which dried blood spot samples were analysed for C-reactive protein (CRP). Retinol-binding protein (RBP) had previously been analysed using a commercial enzyme immunoassay. Setting A population-based study in Uganda. Subjects A systematically selected subset of the dried blood spot samples collected from children aged 6–59 months for UDHS 2006. Children were categorized into ‘normal CRP’ (Group A) and ‘raised CRP’ (Group B) using a CRP cut-off of 5 mg/l. A correction factor was calculated to adjust the Group B RBP values for the influence of the acute-phase response. Results Geometric mean CRP was 6·2 (95 % CI 5·5, 7·0) mg/l, 1·6 (95 % CI 1·5, 1·8) mg/l and 17·9 (95 % CI 16·4, 19·6) mg/l in all children, in Group A and in Group B, respectively. Geometric mean RBP in all children, in Group A and in Group B was 1·18 (95 % CI 1·14, 1·22) μmol/l, 1·26 (95 % CI 1·20, 1·33) μmol/l and 1·12 (95 % CI 1·07, 1·17) μmol/l, respectively, before correction. Correction increased mean RBP in Group B to 1·26 (95 % CI 1·21, 1·31) μmol/l. The prevalence of vitamin A deficiency (RBP Conclusions Correcting for the acute-phase response significantly reduced the prevalence of vitamin A deficiency; thus, the acute-phase response should be considered when vitamin A status is assessed using RBP in order to improve population-level estimates of vitamin A deficiency
C-reactive protein · Dried blood spot · Environmental health · Geometric mean · Group B · Population · Retinol · Retinol binding protein · Vitamin · Vitamin A deficiency · Antioxidant Activity and Oxidative Stress · Chemistry · Medicine · Retinoids in leukemia and cellular processes · Vitamin C and Antioxidants Research · Gastroenterology · Internal Medicine · Pediatrics
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Feasibility of using retinol-binding protein from capillary blood specimens to estimate serum retinol concentrations and the prevalence of vitamin A deficiency in low-resource settings
Vitamin A deficiency and anemia among children 12-71 months old in Honduras
The Use of Dried Blood Spot Sampling in the National Social Life, Health, and Aging Project
What a drop can do
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,15 |
| Citation span | 2013 - 2016 (4) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |