Accounting for the influence of inflammation on retinol‐binding protein in a population survey of Liberian preschool‐age children
Bibliographic Data
| ID | 15535684 |
|---|---|
| Authors | Leila M Larson (0000-0002-2570-7323, Emory University, corresponding author), O Yaw Addo (0000-0003-1269-759X, Emory University), Fanny Sandalinas (0000-0003-0213-4822, West and Central African Council for Agricultural Research and Development), Katherine Faigao (University of Liberia), Roland Kupka (0000-0002-7943-1705, West and Central African Council for Agricultural Research and Development), Rafael Flores‐Ayala (0000-0001-7895-5390, Emory University), Parminder S Suchdev (0000-0002-0350-3469, Emory University) |
| Year | 2016 |
| Volume | 13 |
| Issue | 2 |
| Publication date | 2016-02-04 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.12298 |
| PMID | 26842430 |
| OpenAlex | W2472435832 |
| Language | EN |
| Citations received | 2 |
| References cited | 20 |
Vitamin A deficiency (VAD) is an important contributor to child morbidity and mortality. The prevalence of VAD, measured by retinol-binding protein (RBP) or retinol, is overestimated in populations with a high prevalence of inflammation. We aimed to quantify and adjust for the effect of inflammation on VAD prevalence in a nationally representative survey of Liberian children 6 to 35 months of age. We compared five approaches to adjust RBP for inflammation and estimate VAD prevalence (defined as RBP 5 mg/L or alpha1-acid glycoprotein (AGP) >1 g/)L; (3) multiplying each individual's RBP by an internal correction factor; (4) by an external correction factor; and (5) using regression (corrected RBP = exp(InRBP - β 1 (lnCRP obs -lnCRP ref ) - β 2 (lnAGP obs -lnAGP ref )). Corrected RBP was based on a regression model where reference lnCRP and lnAGP were set to the maximum of the lowest decile. The unadjusted prevalence of VAD was 24.7%. Children with elevated CRP and/or AGP had significantly lower RBP concentrations than their apparently healthy peers (geometric mean RBP 0.79 μmol/L (95% CI: 0.76, 0.82) vs. 0.95 μmol/L (95% CI: 0.92, 0.97), P < 0.001). Using approaches 2-5 resulted in a prevalence of VAD of 11.6%, 14.3%, 13.5% and 7.3%, respectively. Depending on the approach, the VAD prevalence is reduced 10-17 percentage points when inflammation is taken into account. Further quantification of the influence of inflammation on biomarkers of vitamin A status from other national surveys is needed to compare and recommend the preferred adjustment approach across populations
C-reactive protein · Environmental health · Inflammation · Population · Antioxidant Activity and Oxidative Stress · Kawasaki Disease and Coronary Complications · Medicine · Retinoids in leukemia and cellular processes · Gastroenterology · Internal Medicine
Accounting for the influence of inflammation on retinol‐binding protein in a population survey of Liberian preschool‐age children
The importance of controlling for the acute-phase response in the population-based assessment of vitamin A status
Feasibility of using retinol-binding protein from capillary blood specimens to estimate serum retinol concentrations and the prevalence of vitamin A deficiency in low-resource settings
The use and interpretation of serum retinol distributions in evaluating the public health impact of vitamin A programmes
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,2 |
| Citation span | 2016 - 2019 (4) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |