Dietary intake of folate equivalents and risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition (Epic)–Potsdam study
Bibliographic Data
| ID | 15097161 |
|---|---|
| Authors | Dagmar Drogan (German Institute of Human Nutrition), Kerstin Klipstein-Grobusch, Kerstin Klipstein‐grobusch (0000-0002-5462-9889, German Institute of Human Nutrition, corresponding author), Jutta Dierkes (0000-0003-0663-877X, Otto-von-Guericke-Universität Magdeburg), Cornelia Weikert (0000-0003-1756-0146, German Institute of Human Nutrition), Heiner Boeing (0000-0002-3358-1775, German Institute of Human Nutrition) |
| Year | 2006 |
| Volume | 9 |
| Issue | 4 |
| Pages | 465-471 |
| Publication date | 2006-06-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1079/phn2005863 |
| PMID | 16870018 |
| OpenAlex | W2156544626 |
| Language | EN |
| Citations received | 1 |
| References cited | 22 |
Objective To assess the relationship between intake of dietary folate equivalents and risk of myocardial infarction in a German cohort. Design Intake of dietary folate equivalents was assessed by a validated food-frequency questionnaire. Cox proportional hazard models were used to evaluate the association between intake of dietary folate equivalents and risk of myocardial infarction. Setting The European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort, Germany. Subjects Subjects were 22 245 apparently healthy non-users of vitamin supplements aged 35–64 years. Results During 4.6 years of follow-up, 129 incident cases of myocardial infarction were identified. Compared with intake below the median (103 μg), higher intake of dietary folate equivalents was associated with a multivariate-adjusted hazard ratio (HR) of 0.57 (95% confidence interval (CI) 0.36–0.91). The inverse association of folate intake and myocardial infarction risk was stronger in participants with an ethanol intake equal to or above the sex-specific median (HR = 0.37, 95% CI 0.18–0.79) and attenuated in those with a low ethanol intake (HR = 0.67, 95% CI 0.37–1.22). Conclusion An increased intake of dietary folate equivalents was observed to be associated with decreased risk of myocardial infarction in a German study population, pointing towards the importance of folate intake with respect to primary prevention of myocardial infarction
Cohort · Cohort study · Confidence interval · Environmental health · European Prospective Investigation into Cancer and Nutrition · Hazard ratio · Lower risk · Myocardial infarction · Population · Proportional hazards model · Prospective cohort study · Esophageal and GI Pathology · Folate and B Vitamins Research · Medicine · Nutritional Studies and Diet · Internal Medicine · Physiology
| Citations per year | 0.06 |
|---|---|
| Citation span | 2009 - 2009 (1) |
| Highly cited | No |