Association of genetic variants related to combined exposure to higher BMI and waist-to-hip ratio on lifelong cardiovascular risk in UK Biobank

Bibliographic Data

ID15097568
AuthorsEric Yuk Fai Wan (0000-0002-6275-1147, University of Hong Kong, corresponding author), Wing Tung Fung (0009-0005-1665-9875, University of Hong Kong), Esther Yee Tak Yu (0000-0001-7472-7083, University of Hong Kong, corresponding author), Will Ho Gi Cheng (0000-0002-0388-3860, University of Hong Kong), Kam Suen Chan (University of Hong Kong), Yuan Wang (0000-0003-1439-5288, University of Hong Kong), Esther W Chan (0000-0002-7602-9470, University of Hong Kong), Esther Wai Yin Chan, I C K Wong (0000-0001-8242-0014, Laboratory of Data Discovery for Health), Cindy L K Lam (0000-0001-7536-8481, University of Hong Kong - Shenzhen Hospital), Cindy Lo Kuen Lam
Year2023
Volume26
Issue2
Pages416-424
Publication date2023-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePublic Health Nutrition (JOURNAL)
Journal identifiersISSN: 1368-9800 • E-ISSN: 1475-2727
PublisherCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980022001276
PMID35621080
OpenAlexW4281633142
LanguageEN
References cited47

Objective: This study examines the individual and combined association of BMI and waist-to-hip ratio (WHR) with CVD risk using genetic scores of the obesity measurements as proxies. Design: A 2 × 2 factorial analysis approach was applied, with participants divided into four groups of lifetime exposure to low BMI and WHR, high BMI, high WHR, and high BMI and WHR based on weighted genetic risk scores. The difference in CVD risk across groups was evaluated using multivariable logistic regression. Setting: Cohort study. Participants: A total of 408 003 participants were included from the prospective observational UK Biobank study. Results: A total of 58 429 CVD events were recorded. Compared to the low BMI and WHR genetic scores group, higher BMI or higher WHR genetic scores were associated with an increase in CVD risk (high WHR: OR, 1·07; 95 % CI (1·04, 1·10)); high BMI: OR, 1·12; 95 % CI (1·09, 1·16). A weak additive effect on CVD risk was found between BMI and WHR (high BMI and WHR: OR, 1·16; 95 % CI (1·12, 1·19)). Subgroup analysis showed similar patterns between different sex, age ( Conclusions: High BMI and WHR were associated with increased CVD risk, and their effects are weakly additive. Even though there were overlapping of effect, both BMI and WHR are important in assessing the CVD risk in the general population

Biobank · Bioinformatics · Biology · Body mass index · Logistic regression · Obesity · Odds ratio · Prospective cohort study · Waist · Waist–hip ratio · Cardiovascular Disease and Adiposity · Demography · Genetic Associations and Epidemiology · Medicine · Obesity, Physical Activity, Diet · Internal Medicine

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