The Impact of the Deepwater Horizon Oil Spill upon Lung Health—Mouse Model-Based RNA-Seq Analyses
Bibliographic Data
| ID | 15460778 |
|---|---|
| Authors | Yaozhong Liu (0000-0003-1994-2025, Tulane University, corresponding author), Charles A Miller (0000-0003-0644-7455, Tulane University), Yan Zhuang (0000-0003-1245-7203, Tulane University), Sudurika Mukhopadhyay (Tulane University), Sudurika S Mukhopadhyay (Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA), Shigeki Saito (0000-0001-6377-7173, Tulane University), Edward B Overton (Louisiana State University), Gilbert F Morris (0000-0002-4540-8099, Tulane University) |
| Year | 2020 |
| Volume | 17 |
| Issue | 15 |
| Pages | 5466-5466 |
| Publication date | 2020-07-29 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17155466 |
| PMID | 32751227 |
| OpenAlex | W3045530364 |
| Language | EN |
| Citations received | 2 |
| References cited | 48 |
We used a transcriptomic approach to interrogate the effects of a saline-accommodated fraction from the Macondo 252 well (MC252) oil and Corexit dispersants on lung tissue. Wild-type C57BL/6 male and female mice were exposed on days 0, 7 and 13 by oropharyngeal aspiration to saline accommodated fractions (SAF) of crude oil from the Macondo (MC252) well, Corexit 9500, Corexit 9527, 9500+oil and 9527+oil or a saline solution as the vehicle control. These treatments did not cause overt toxicity, with the exception of the Corexit exposures which caused brief weight loss after the first exposure. On day 14, total RNA was isolated from the left lung for RNA-seq analyses. KEGG-pathway-based differential expression revealed that Corexit 9527 elicited the strongest changes involving the upregulation of 19 KEGG pathways (FDR LA1 mice provided evidence for tumor promotion by oil and Corexit dispersant treatments. Our mouse RNA-seq analyses may be relevant to the pulmonary health hazards of MC252 oil and dispersants experienced in exposed populations
Biology · Dispersant · Downregulation and upregulation · Gene expression · Lung · Saline · Transcriptome · Tumor necrosis factor alpha · Chemistry · Medicine · Oil Spill Detection and Mitigation · Biochemistry · Cell Biology · Endocrinology · Environmental Chemistry · Immunology · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,4 |
| Citation span | 2021 - 2024 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |