Pollutants, microbiota and immune system
Frenemies within the gut
Bibliographic Data
| ID | 22089335 |
|---|---|
| Authors | Pierluigi Rio (0000-0002-8659-3091, Ahvaz Jundishapur University of Medical Sciences), Antonio Gasbarrini (0000-0002-6230-1779, Ahvaz Jundishapur University of Medical Sciences), Giovanni Gambassi (Ahvaz Jundishapur University of Medical Sciences), Rossella Cianci (0000-0001-5378-8442, Ahvaz Jundishapur University of Medical Sciences, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Pages | 1285186-1285186 |
| Publication date | 2024-05-10 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2024.1285186 |
| PMID | 38799688 |
| OpenAlex | W4396808582 |
| Language | EN |
| Citations received | 1 |
| References cited | 215 |
Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite a widespread lack of awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing its regulation and triggering pro-inflammatory responses. The exposure to several pollutants also leads to alterations in gut microbiota with a decreasing abundance of beneficial microbes, such as short-chain fatty acid-producing bacteria, and an overgrowth of pro-inflammatory species. The subsequent intestinal barrier dysfunction, together with oxidative stress and increased inflammatory responses, plays a role in the pathogenesis of gastrointestinal inflammatory diseases. Moreover, pollutants encourage the inflammation-dysplasia-carcinoma sequence through various mechanisms, such as oxidative stress, dysregulation of cellular signalling pathways, cell cycle impairment and genomic instability. In this narrative review, we will describe the interplay between pollutants, gut microbiota, and the immune system, focusing on their relationship with inflammatory bowel diseases and colorectal cancer. Understanding the biological mechanisms underlying the health-to-disease transition may allow the design of public health policies aimed at reducing the burden of disease related to pollutants
Biology · Disease · Gut flora · Immune system · Inflammation · Oxidative stress · Pathology · Pollutant · Air Quality and Health Impacts · Climate Change and Health Impacts · Gut microbiota and health · Inflammatory Bowel Disease · Medicine · Ecology · Immunology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |