Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle

A Comparison of Airway Immune Responses

Bibliographic Data

ID15460831
AuthorsJuliana M B Santos (0000-0003-0527-0723, Universidade Federal de São Paulo, corresponding author), Roberta Foster (0000-0002-9986-9747, Universidade Federal de São Paulo), Anne‐Charlotte Jonckheere (0000-0003-4943-892X, KU Leuven), Marcelo Rossi (0000-0003-4627-8692, Universidade Federal de São Paulo), Luiz Luna (Universidade Federal de São Paulo), Luiz Antonio Luna Junior (ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil), Catherine Machado Katekaru (Universidade Federal de São Paulo), Matheus Cavalcante de Sá (0000-0002-0718-8814, Universidade Federal de São Paulo), Lucas Guimarães Pagani (Universidade Federal de São Paulo), Francine Maria de Almeida (0000-0001-9755-5034, Universidade de São Paulo), Jônatas Bussador do Amaral (0000-0001-5819-0474, Universidade Federal de São Paulo), Rodolfo P Vieira (0000-0001-6379-1143, Anhembi Morumbi University), André Luís Lacerda Bachi (0000-0001-8266-1416, Universidade Brasil), Dominique Bullens (0000-0002-4595-9579, Universitair Ziekenhuis Leuven), Dominique Magdalena A Bullens (KU Leuven), Mauro Vaisberg (0000-0003-0292-3792, Universidade Federal de São Paulo)
Year2019
Volume16
Issue22
Pages4418-4418
Publication date2019-11-12
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph16224418
PMID31726719
OpenAlexW2984473375
LanguageEN
Citations received3
References cited69

Although regular exercise-training improves immune/inflammatory status, the influence of air pollutants exposure during outdoor endurance training compared to a sedentary lifestyle has not yet been clarified. This study aimed to compare the immune/inflammatory responses in the airways of street runners and sedentary people after acute and chronic particulate matter (PM) exposure. Forty volunteers (street runners (RUN, n = 20); sedentary people (SED, n = 20)) were evaluated 1 (acute) and 10 (chronic) weeks after PM exposure. Cytokines [interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-13, and IL-17A] in nasal lavage fluid, salivary antibacterial peptides (lactoferrin (LTF), cathelicidin (LL-37), defensin-α 1-3), and secretory immunoglobulin A (SIgA), plasma club cell protein (CC16), and fractional exhaled nitric oxide (FeNO) were analyzed. After acute exposure, the RUN group showed lower levels of IL-13, IL-10, and FeNO, but higher defensin-α than the SED group. After chronic exposure, the RUN group showed elevation of IFN-γ, IL-10, IL-17A, and a decrease of FeNO levels, whereas the SED group showed elevation of TNF-α, IL-6, IL-10, and a decrease of IL-13 levels. Comparing these groups, the RUN group showed higher levels of SIgA and LTF, and lower FeNO levels than the SED group. In relation to the Th immune response analysis after acute and chronic PM exposure, the RUN group showed a pattern associated with Th1, while in the SED group, a Th2 pattern was found. Both groups showed also a Th17 immune response pattern. Our results allow us to suggest that the immune/inflammatory status of the respiratory tract after acute and chronic PM exposure was improved by the long-standing regular practice of outdoor endurance exercise compared to a sedentary lifestyle

Air pollutants · Air pollution · Airway · Biology · Endurance Training · Environmental health · Geography · Immune system · Meteorology · Physical therapy · Training (meteorology · Air Quality and Health Impacts · Exercise and Physiological Responses · Indoor Air Quality and Microbial Exposure · Medicine · Ecology · Immunology

Tools

Open DOISci-HubOpen Access