The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction

Bibliographic Data

ID15464479
AuthorsJuliana M B Santos (0000-0003-0527-0723, Universidade Federal de São Paulo, corresponding author), André Luís Lacerda Bachi (0000-0001-8266-1416, Universidade de Santo Amaro), Luiz Luna (Universidade Federal de São Paulo), Luiz Antonio Luna Junior (Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil), Roberta Foster (0000-0002-9986-9747, Universidade Federal de São Paulo), Ana Sierra (0000-0001-9845-418X, Universidade de São Paulo), Ana Paula Renno Sierra (School of Physical Education and Sport, University of São Paulo (USP), São Paulo 05508-030, Brazil), Marino Benetti (Universidade de São Paulo), José Roberto Araújo (Universidade Federal de São Paulo), Nabil Ghorayeb (0000-0002-7056-7593, Instituto Dante Pazzanese de Cardiologia), Maria Augusta Peduti Dal’Molim Kiss (Universidade de São Paulo), Rodolfo P Vieira (0000-0001-6379-1143, Anhembi Morumbi University), Dominique Bullens (0000-0002-4595-9579, Universitair Ziekenhuis Leuven), Dominique M A Bullens (Universitair Ziekenhuis Leuven), Mauro Vaisberg (0000-0003-0292-3792, Universidade Federal de São Paulo)
Year2020
Volume17
Issue8
Pages2622-2622
Publication date2020-04-11
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17082622
PMID32290385
OpenAlexW3016220187
LanguageEN
Citations received2
References cited54

At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 [33-44], height 175.7 [172.0-180.3]; weight 74.7 [69.3-81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB-) (EIB+ 44.02 [39.56-47.02] and EIB- 47.62 [44.11-51.18] p = 0.03). The comparison of plasma levels of IL-1β (EIB+ p = 0.296, EIB- p = 0.176, EIB+ vs. EIB- baseline p = 0.190 immediately after p = 0.106), IL-4 (undetectable), IL-6 (EIB+ p = 0.003, EIB- p ≤ 0.001, EIB+ vs. EIB- baseline p = 0.301 immediately after p = 0.614), IL-8 (EIB+ p = 0.003, EIB- p ≤ 0.001, EIB+ vs. EIB- baseline p = 0.110 immediately after p = 0.453), IL-10 (EIB+ p = 0.003, EIB- p ≤ 0.001, EIB+ vs. EIB- baseline p = 0.424 immediately after p = 0.876) and TNF-α (EIB+ p = 0.003, EIB- p ≤ 0.001, EIB+ vs. EIB- baseline p = 0.141 immediately after p = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = -0.81, p = 0.022), and IL-10 (r = -0.97, p ≤ 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB

Asthma · Bronchoconstriction · Physical therapy · Asthma and respiratory diseases · Chronic Obstructive Pulmonary Disease (COPD) Research · Exercise and Physiological Responses · Medicine · Internal Medicine

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