Trypsin-Like Activity in Oral Cavity Is Associated with Risk of Fever Onset in Older Residents of Nursing Homes
An 8-Month Longitudinal Prospective Cohort Pilot Study
Bibliographic Data
| ID | 15460912 |
|---|---|
| Authors | Maya Izumi (Kyushu Dental University), Ayaka Isobe (Kyushu Dental University), Sumio Akifusa (0000-0001-7962-8762, Kyushu Dental University, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 5 |
| Pages | 2255-2255 |
| Publication date | 2021-02-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18052255 |
| PMID | 33668733 |
| OpenAlex | W3133291732 |
| Language | EN |
| Citations received | 1 |
| References cited | 37 |
This study aimed to evaluate the association between trypsin-like activity in the oral cavity and the onset of fever in independent older residents of nursing homes. Independent older residents aged ≥ 65 years in 10 nursing homes were included in this study, which was conducted in Kitakyushu, Japan. For 8 months, follow-up dates on which the body temperatures of participants were more than 37.2 °C were noted. Trypsin-like activity in the oral cavity was detected by ADCHECK® with five-grade evaluation at baseline. Data from 53 independent participants with median age 89.0 (67–102) years were available for analysis. ADCHECK® scores were associated with fever days (r = 0.312, p = 0.029). The average periods until the onset of fever in participants with ADCHECK® Scores 1 and 2, Score 3, and Scores 4 and 5 were 6.6 ± 0.5, 5.0 ± 0.7, and 4.1 ± 1.0 months, respectively. ADCHECK® Scores 4 and 5 signified a higher risk of fever compared to ADCHECK® Scores 1 and 2 (hazards ratio 5.9, 95% confidence interval 1.4–23.9, p = 0.013), adjusted for possible confounders. We concluded that trypsin-like activity in the oral cavity was associated with the risk of fever in independent older residents of nursing homes
Cohort · Cohort study · Confidence interval · Confounding · Longitudinal study · Nursing homes · Oral cavity · Prospective cohort study · Relative risk · Dentistry · Medicine · Nosocomial Infections in ICU · Nursing · Oral microbiology and periodontitis research · Pediatric health and respiratory diseases · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |