The Association between Tannerella forsythia and the Onset of Fever in Older Nursing Home Residents
A Prospective Cohort Study
Bibliographic Data
| ID | 15487588 |
|---|---|
| Authors | Ayaka Koga (0009-0008-6259-6432, Kyushu Dental University), Wataru Ariyoshi (0000-0002-6533-5683, Kyushu Dental University), Kaoru Kobayashi (0000-0003-3764-7724, Kyushu Dental University), Maya Izumi (Kyushu Dental University), Ayaka Isobe (Kyushu Dental University), Sumio Akifusa (0000-0001-7962-8762, Kyushu Dental University, corresponding author), Tatsuji Nishihara (0000-0001-7075-9678, Kyushu Dental University) |
| Year | 2022 |
| Volume | 19 |
| Issue | 8 |
| Pages | 4734-4734 |
| Publication date | 2022-04-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19084734 |
| PMID | 35457601 |
| OpenAlex | W4224017684 |
| Language | EN |
| References cited | 51 |
Background: Periodontal pathogens are related to the incidence of systemic diseases. This study aimed to examine whether periodontal pathogen burden is associated with the risk of fever onset in older adults. Methods: Older adults in nursing homes, aged ≥65 years, were enrolled. The study was set in Kitakyushu, Japan. The body temperatures of participants were ≥37.2 °C and were recorded for eight months. As periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia were qualified by a real-time polymerase chain reaction at the baseline. For statistical analysis, the number of bacterial counts was logarithmically conversed to 10 as a base. Results: Data from 56 participants with a median age of 88 (62−98) years were available for analysis. The logarithmic-conversed bacterial counts of T. forsythia, but not P. gingivalis or T. denticola, were associated with the onset of fever in older residents. The Kaplan−Meier method revealed that the group with <104 of T. forsythia had significantly less cumulative fever incidence than the group with ≥104 of T. forsythia. The group with ≥104 of T. forsythia was associated with an increased risk of fever onset (hazard ratio, 3.7; 98% confidence interval, 1.3−10.2; p = 0.012), which was adjusted for possible confounders. Conclusions: Bacterial burden of T. forsythia in the oral cavity was associated with the risk of the onset of fever in older nursing homes residents
Cohort · Cohort study · Confidence interval · Cumulative incidence · Forsythia · Hazard ratio · Incidence (geometry · Periodontitis · Porphyromonas gingivalis · Tannerella forsythia · Treponema denticola · Dental Health and Care Utilization · HIV/AIDS oral health manifestations · Medicine · Oral microbiology and periodontitis research · Internal Medicine
| Highly cited | No |
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