Covid-19 Infections Still Occur

How Do Pregnant and Non-Pregnant Individuals Compare? A Study from the Canadian Mother–Child Initiative on Drug Safety in Pregnancy (CAMCCO)

Bibliographic Data

ID15464425
AuthorsAnick Berard (0000-0001-7535-5517, Lyon 1 Université, corresponding author), Odile Sheehy (0000-0002-6784-2080, Centre Hospitalier Universitaire Sainte-Justine), Padma Kaul (0000-0003-2239-3944, University of Alberta), Sherif Eltonsy (0000-0002-0520-5406, University of Manitoba), Mark Walker (0000-0002-0507-1954, University of Ottawa), Mark S Walker (0000-0002-3276-2689, University of Ottawa), Steven Hawken (0000-0002-3341-9022, University of Ottawa), Sasha Bernatsky (0000-0002-9515-2802, McGill University), Michael Pugliese (0000-0003-2794-1436, University of Ottawa), Olesya Barrett (University of Alberta), Anamaria Savu (0000-0001-8070-4195, University of Alberta), Roxana Drăgan (0000-0002-9744-3590, University of Manitoba)
Year2025
Volume22
Issue11
Pages1756-1756
Publication date2025-11-20
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph22111756
PMID41302700
OpenAlexW4416400910
LanguageEN
References cited14

Over 100 million pregnant people worldwide remain at risk of COVID-19. We compared the prevalence of severe COVID-19 in pregnancy and in people of reproductive age, and the risk of adverse pregnancy/neonatal outcomes in those with/without COVID-19 during gestation. In the Canadian Mother-Child Cohort, two sub-cohorts were identified using medical services, prescription medication fillings, hospitalizations, and COVID-19 surveillance testing programs data (28 February 2020-2021). The first included all pregnant people with at least one completed trimester of pregnancy during the study period, stratified on COVID-19 status. The second included all non-pregnant people (aged 15-45) with a positive COVID-19 test during the same period. COVID-19 severity was categorized based on hospital admissions before the end of pregnancy. Associations between COVID-19 during pregnancy and adverse perinatal outcomes were quantified using log-binomial regressions. A total of 150,345 pregnant people (3464 (2.3%) had COVID-19), and 112,073 non-pregnant people with COVID-19 were included. Maternal age at the time of COVID-19 diagnosis/positive test was statistically significantly lower among pregnant individuals compared to those who were not pregnant (96% had less than 40 years vs. 80%, p < 0.001). In pregnancy, COVID-19 was associated with the risk of spontaneous abortions (adjRR 1.76, 95%CI 1.37, 2.25), gestational diabetes (adjRR 1.52, 95%CI 1.18, 1.97), prematurity (adjRR 1.30, 95%CI 1.01, 1.67), and NICU (adjRR 1.32, 95%CI 1.10, 1.59); COVID-19 treatment with medications reduced risks. Severe COVID-19 was more prevalent in pregnancy and was associated with higher risks of adverse maternal/neonatal outcomes. As some countries are pulling back preventive strategies for COVID-19, this study highlights the importance of continued surveillance during pregnancy to prevent adverse pregnancy outcomes

Adverse effect · First trimester · Gestation · Gestational age · Gestational diabetes · Medical prescription · Pregnancy · Risk assessment · Young adult · COVID-19 Impact on Reproduction · Gestational Diabetes Research and Management · Maternal Mental Health During Pregnancy and Postpartum