Mouth-Level Intake of Benzo[a]pyrene from Reduced Nicotine Cigarettes
Bibliographic Data
| ID | 15465252 |
|---|---|
| Authors | Yan S Ding (National Center for Environmental Health, corresponding author), Jennye Ward (National Center for Environmental Health), D Hammond (0000-0001-8197-6010, University of Waterloo), Clifford H Watson (0000-0003-0480-4092, Centers for Disease Control and Prevention) |
| Year | 2014 |
| Volume | 11 |
| Issue | 11 |
| Pages | 11898-11914 |
| Publication date | 2014-11-18 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph111111898 |
| PMID | 25411724 |
| PMCID | PMC4245650 |
| OpenAlex | W2046605284 |
| Language | EN |
| Citations received | 3 |
| References cited | 1 |
Cigarette smoke is a known source of exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), especially benzo[a]pyrene (BaP). Exposure to BaP in cigarette smoke is influenced by how a person smokes and factors, such as tobacco blend. To determine whether sustained use of reduced-nicotine cigarettes is associated with changes in exposure to nicotine and BaP, levels of BaP in spent cigarette filter butts were correlated with levels of BaP in cigarette smoke to estimate mouth-level intake (MLI) of BaP for 72 daily smokers given three progressively reduced nicotine content cigarettes. Urinary cotinine, a marker of nicotine exposure, and urinary 1-hydroxypyrene (1-HOP), a marker of PAH exposure, were measured throughout the study. Median daily BaP MLI and urine cotinine decreased in a similar manner as smokers switched to progressively lower nicotine cigarettes, despite relatively constant daily cigarette consumption. 1-HOP levels were less responsive to the use of reduced nicotine content cigarettes. We demonstrate that spent cigarette filter butt analysis is a promising tool to estimate MLI of harmful chemicals on a per cigarette or per-day basis, which partially addresses the concerns of the temporal influence of smoking behavior or differences in cigarette design on exposure
Animal science · Benzo(a)pyrene · Biology · Carcinogen · Cigarette smoke · Cotinine · Environmental health · Nicotine · Pyrene · Smoke · Tobacco smoke · Urine · Carcinogens and Genotoxicity Assessment · Chemistry · Medicine · Smoking Behavior and Cessation · Toxic Organic Pollutants Impact · Biochemistry · Food Science · Internal Medicine · Physiology · Toxicology
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,3 |
| Citation span | 2016 - 2022 (7) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |