Environmental Lead Exposure and Influenza and Respiratory Syncytial Virus Diagnoses in Young Children
A Test-Negative Case-Control Study
Bibliographic Data
| ID | 15465804 |
|---|---|
| Authors | Marina Oktapodas Feiler (0000-0002-2315-9589, University of Rochester, corresponding author), Mary T Caserta (0000-0002-3813-0762, University of Rochester), Edwin van Wijngaarden (0000-0001-7583-4630, University of Rochester), Kelly Thevenet-Morrison (University of Rochester), Dwight J Hardy (University of Rochester), Yan Victoria Zhang (University of Rochester), Ann M Dozier (University of Rochester), Ann Dozier (0000-0001-8296-1910, University of Rochester), B Paige Lawrence (0000-0003-4882-9750, University of Rochester), Todd A Jusko (0000-0002-3194-6718, University of Rochester) |
| Year | 2020 |
| Volume | 17 |
| Issue | 20 |
| Pages | 7625-7625 |
| Publication date | 2020-10-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17207625 |
| PMID | 33086756 |
| OpenAlex | W3092953529 |
| Language | EN |
| Citations received | 1 |
| References cited | 36 |
Experimental and epidemiological evidence suggests that environmental toxicants may influence susceptibility to influenza and respiratory syncytial virus (RSV). The objective of the present study was to estimate the association between blood lead concentrations and the odds of child influenza or RSV infection. A test-negative, case-control study was conducted among 617 children, <4 years of age, tested for influenza/RSV from 2012-2017 in Rochester, NY. There were 49 influenza cases (568 controls) and 123 RSV cases (494 controls). Blood lead concentrations reported in children's medical records were linked with influenza/RSV lab test results. Covariables were collected from medical records, birth certificates, and U.S. census data. In this sample, evidence of an association between blood lead levels and RSV or influenza diagnosis was not observed. Children with a lead level ≥1 μg/dL vs. <1 μg/dL had an adjusted odds ratio (aOR) and 95% confidence limit of 0.95 (0.60, 1.49) for RSV and 1.34 (0.65, 2.75) for influenza. In sex-specific analyses, boys with lead concentrations ≥1 μg/dL vs. <1 μg/dL had an aOR = 1.89 (1.25, 2.86) for influenza diagnosis, while the estimates were inconsistent for girls. These results are suggestive of sex-specific associations between blood lead levels and the risk of influenza, although the sample size was small
Blood lead level · Case-control study · Confidence interval · Lead exposure · Odds ratio · Respiratory system · Virus · Medicine · Neonatal Respiratory Health Research · Respiratory viral infections research · Viral gastroenteritis research and epidemiology · Epidemiology · Immunology · Internal Medicine · Pediatrics
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |