HPV Vaccine Hesitancy and Influencing Factors among University Students in China

A Cross-Sectional Survey Based on the 3Cs Model

Bibliographic Data

ID15468241
AuthorsYan Huang (0000-0003-3591-7532, Sun Yat-sen University), Cheng Chen (0000-0002-3583-9370, Wuhan University of Science and Technology), Lei Wang (0000-0001-5326-565X, Jinan University), Hua-Mei Wu (Hubei Urban Construction Vocational and Technological College), Ting Chen (0009-0007-4319-1117, Wuhan University of Science and Technology, corresponding author), Luying Zhang (0000-0001-8427-7063, Fudan University, corresponding author)
Year2022
Volume19
Issue21
Pages14025-14025
Publication date2022-10-28
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph192114025
PMID36360905
OpenAlexW4307939363
LanguageEN
Citations received7
References cited6

The burden of disease caused by cervical cancer ranked second among female tumors in China. The HPV vaccine has been proven to be a cost-effective measure to prevent cervical cancer, but the vaccination rate remained low to date among university students. This study aimed to understand the status quo of HPV vaccine hesitancy among university students across China during the COVID-19 pandemics and systematically analyze determinants of HPV vaccine hesitancy based on the WHO 3Cs model. Cross-sectional data were collected using an online survey of female university students in four cities across China in June 2022. Multinomial logistic regression was adopted to determine factors influencing vaccine hesitancy based on the 3Cs model with three dimensions, namely complacency, convenience, and confidence. Among 1438 female university students surveyed in this study, 89.7% did not hesitate to vaccinate against HPV, only 8.9% hesitated to some extent, and 1.4% refused to vaccinate. The actual vaccination rate for the HPV vaccine was 34.2%. Based on the 3Cs model, this study found that the trust on the efficacy of vaccines, risk perception of being infected by HPV, price, and distance/time were influencing factors of vaccine hesitancy. Knowledge of the HPV vaccine and sociodemographic characteristics, such as education levels, were also statistically relevant. Therefore, it is recommended that relevant scientific knowledge on cervical cancer and the HPV vaccine should be spread on campus, the vaccination appointment procedure should be simplified, and the affordability of vaccination should be increased through strategic purchasing or providing subsidies, so as to reduce HPV vaccine hesitancy

Cancer · Cervical cancer · China · Coronavirus disease 2019 (COVID-19 · Cross-sectional study · Disease · Environmental health · Family medicine · Logistic regression · Misinformation · Pandemic · Political science · Sociology · Status quo · Vaccination · Cervical Cancer and HPV Research · Demography · Hepatitis B Virus Studies · Medicine · Vaccine Coverage and Hesitancy · Internal Medicine · Virology

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