Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes

A Cross-Sectional Study

Bibliographic Data

ID15468580
AuthorsAida Kalok (0000-0001-5475-093X, National University of Malaysia, corresponding author), Ming Yean Ong (0000-0003-2200-8188, National University of Malaysia), Aqilah Hasrori (National University of Malaysia), Ker Shing Chiang (0000-0001-5404-6395, National University of Malaysia), Fatin Yazim (National University of Malaysia), Salahuddin Baharuddin (National University of Malaysia), Rahana Abd Rahman (0000-0003-4161-6461, National University of Malaysia), Shamsul Azhar Shah (0000-0003-0635-1816, National University of Malaysia), Nor Haslinda Abd Aziz (0000-0002-4632-7135, National University of Malaysia), Shuhaila Ahmad (0000-0003-3722-3948, National University of Malaysia), Nor Azlin Mohamed Ismail (National University of Malaysia)
Year2020
Volume17
Issue19
Pages6990-6990
Publication date2020-09-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17196990
PMID32987806
OpenAlexW3087837540
LanguageEN
References cited35

Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients' demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45-15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93-39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04-0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings

Diabetes mellitus · Gestation · Gestational diabetes · Hypoglycemia · Neonatal hypoglycemia · Obstetrics · Odds ratio · Postprandial · Preeclampsia · Pregnancy · Bariatric Surgery and Outcomes · Gestational Diabetes Research and Management · Medicine · Pregnancy and preeclampsia studies · Endocrinology · Internal Medicine

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