First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

Bibliographic Data

ID15510693
AuthorsFederica Visconti (0000-0002-5548-2751, Magna Graecia University), Paola Quaresima (0000-0002-5081-5430, Magna Graecia University), Eusebio Chiefari (0000-0001-5329-3124, Magna Graecia University), Patrizia Caroleo (Azienda Ospedaliera Pugliese Ciaccio), Biagio Arcidiacono (0000-0003-4343-678X, Magna Graecia University), Luigi Puccio (Azienda Ospedaliera Pugliese Ciaccio), Maria Mirabelli (0000-0002-6427-7186, Magna Graecia University), Daniela Foti (0000-0002-9536-5736, Magna Graecia University), Daniela P Foti (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy), Costantino Di Carlo (0000-0002-4119-9824, Magna Graecia University), Raffaella Vero (Azienda Ospedaliera Pugliese Ciaccio), Antonio Brunetti (0000-0003-1533-8779, Magna Graecia University, corresponding author)
Year2019
Volume16
Issue19
Pages3654-3654
Publication date2019-09-28
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph16193654
PMID31569431
OpenAlexW2976349107
LanguageEN
Citations received2
References cited38

Background -The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods -2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11-13 weeks (plus 6 days) of gestation, and screening for GDM at 16-18 and/or 24-28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results -1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis ( ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT p = 0.016), similar to women with a PAPP-A p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM ( p = 0.014). Conclusions -Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM

Advanced maternal age · Aneuploidy · Biology · Diabetes mellitus · Fetus · Gestation · Gestational age · Gestational diabetes · Gynecology · Hormone · Human chorionic gonadotropin · Logistic regression · Multivariate analysis · Obstetrics · Pregnancy · Univariate analysis · Gestational Diabetes Research and Management · Medicine · Pregnancy and preeclampsia studies · Prenatal Screening and Diagnostics · Endocrinology · Internal Medicine

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