Aberrant Production of Th1/Th2/Th17-Related Cytokines in Serum of C57BL/6 Mice after Short-Term Formaldehyde Exposure
Bibliographic Data
| ID | 15468632 |
|---|---|
| Authors | Haiyan Wei (0000-0001-5490-8995, Southeast University, corresponding author), Kehong Tan (Southeast University), Rongli Sun (0000-0003-1694-5319, Southeast University), Lihong Yin (0000-0001-9673-3193, Southeast University), Juan Zhang (0000-0003-3613-6332, Southeast University), Yuepu Pu (0000-0003-4710-3018, Southeast University) |
| Year | 2014 |
| Volume | 11 |
| Issue | 10 |
| Pages | 10036-10050 |
| Publication date | 2014-09-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph111010036 |
| PMID | 25264680 |
| PMCID | PMC4210965 |
| OpenAlex | W2018841156 |
| Language | EN |
| Citations received | 1 |
| References cited | 53 |
Previous studies have shown that formaldehyde (FA) could cause immunotoxicity by changing the number of T lymphocytes and that cytokines play a pivotal role in the regulation of T lymphocytes. However, the previously used cytokine detection methods are difficult to use in the measurement of several cytokines in a small amount of sample for one test. Therefore, the cytometric bead array (CBA) technique was used. CBA showed better analytical efficiency and sensitivity than the previous methods. C57BL/6 mice were exposed to the control (normal saline), low FA concentration (0.5 mg/kg), and high FA concentration (2 mg/kg) for 1 week or 1 month. The contents of cytokines, including Th1-related cytokines (IL-2, IFN-γ, and tumor necrosis factor), Th2-related cytokines (IL-4, IL-6, and IL-10), and Th17-related cytokines (IL-17A), were measured by using the BD FACS Canto II Flow Cytometer and analyzed by FCAP ArrayTM Software. Th1/Th2/Th17-related cytokines showed a slightly decreasing trend after low FA exposure. Conversely, a significantly increasing trend was found after high FA exposure. Th1/Th2/Th17-related cytokines all serve important functions in the immune reactions in mice after FA exposure
Biology · Cytokine · Formaldehyde · Immune system · Inflammation · Interleukin · Proinflammatory cytokine · Tumor necrosis factor alpha · Air Quality and Health Impacts · Asthma and respiratory diseases · Chemistry · Indoor Air Quality and Microbial Exposure · Biochemistry · Immunology
| Citations per year | 0.13 |
|---|---|
| Citation span | 2018 - 2018 (1) |
| Highly cited | No |