Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B1

Bibliographic Data

ID15470058
AuthorsNa Liang (0000-0003-2185-0007, Sichuan Agricultural University), Fengyuan Wang (0000-0003-2373-0316, Sichuan Agricultural University), Xi Peng (0000-0001-8285-2757, Sichuan Agricultural University, corresponding author), Jing Fang (0000-0002-1589-4188, Sichuan Agricultural University, corresponding author), Hengmin Cui (0000-0003-2963-531X, Sichuan Agricultural University), Zhengli Chen (0000-0002-9850-528X, Sichuan Agricultural University), Weimin Lai (Sichuan Agricultural University), Yi Zhou (0000-0001-6130-687X, Sichuan Agricultural University), Yi Geng (0000-0001-7833-6303, Sichuan Agricultural University)
Year2015
Volume12
Issue9
Pages11196-11208
Publication date2015-09-09
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph120911196
PMID26371027
OpenAlexW2149525000
LanguageEN
References cited39

To evaluate the renal toxicity of dietary aflatoxin B1 (AFB1) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers were divided into four groups, namely control group, AFB1 group (0.3 mg/kg AFB1), +Se group (0.4 mg/kg Se), and AFB1+Se group (0.3 mg/kg AFB1+0.4 mg/kg Se). Compared with that of the control group, the relative weight of kidney was increased in the AFB1 group. There were no significant differences between the AFB1+Se group and the control group. By histopathological observation, the renal epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally, the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the AFB1 group. Enlarged mitochondria with degenerated cristae were observed in the +Se group. Compared with the control group, the contents of serum creatinine and serum uric acid in the AFB1 group were increased, while the activity of renal Na+-K+ ATPase was decreased. When 0.4 mg/kg selenium was added into the diet containing 0.3 mg/kg AFB1, there were no obvious histological changes in the AFB1+Se group, and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na+-K+ ATPase were close to those in the control group. In conclusion, sodium selenite exhibited protective effects on AFB1-induced kidney toxicity in broilers

Aflatoxin · Biology · Broiler · Creatinine · Kidney · Nephrotoxicity · Renal function · Selenium · Sodium · Toxicity · Uric acid · Chemistry · Heavy Metal Exposure and Toxicity · Medicine · Selenium in Biological Systems · Trace Elements in Health · Biochemistry · Endocrinology · Food Science · Internal Medicine