Protective Effects of Sodium Selenite against Aflatoxin B1-Induced Oxidative Stress and Apoptosis in Broiler Spleen
Bibliographic Data
| ID | 15484816 |
|---|---|
| Authors | Fengyuan Wang (0000-0003-2373-0316, Sichuan Agricultural University), Gang Shu (0000-0002-0610-9635, Sichuan Agricultural University), Xi Peng (0000-0001-8285-2757, Sichuan Agricultural University, corresponding author), Jing Fang (0000-0002-1589-4188, Sichuan Agricultural University, corresponding author), Kejie Chen (0000-0003-2207-6885, Sichuan Agricultural University), Hengmin Cui (0000-0003-2963-531X, Sichuan Agricultural University), Zhengli Chen (0000-0002-9850-528X, Sichuan Agricultural University), Zhicai Zuo (0000-0002-5547-4436, Sichuan Agricultural University), Junliang Deng (0000-0002-7159-1923, Sichuan Agricultural University), Yi Geng (0000-0001-7833-6303, Sichuan Agricultural University), Weimin Lai (Sichuan Agricultural University) |
| Year | 2013 |
| Volume | 10 |
| Issue | 7 |
| Pages | 2834-2844 |
| Publication date | 2013-07-09 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph10072834 |
| PMID | 23839060 |
| PMCID | PMC3734461 |
| OpenAlex | W2018133458 |
| Language | EN |
| Citations received | 6 |
The aim of this study was to investigate the possible protective role of sodium selenite on aflatoxin B1-induced oxidative stress and apoptosis in spleen of broilers. Two hundred one-day-old male broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 group), 0.3 mg/kg AFB1 + 0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB1 + 0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB1 + 0.6 mg/kg Se (+Se group III), respectively. According to biochemical assays, AFB1 significantly decreased the activities of glutathione peroxidase, total superoxide dismutase, glutathione reductase, catalase and the level of glutathione hormone, while it increased the level of malondialdehyde. Moreover, AFB1 increased the percentage of apoptosis cells by flow cytometry and the occurrence of apoptotic cells by TUNEL assay. Simultaneous supplementation with sodium selenite restored these parameters to be close to those in control group. In conclusion, sodium selenite exhibited protective effects on AFB1-induced splenic toxicity in broilers by inhibiting oxidative stress and excessive apoptosis
Aflatoxin · Antioxidant · Apoptosis · Biology · Broiler · Catalase · Enzyme · Glutathione · Glutathione peroxidase · Glutathione reductase · Malondialdehyde · Oxidative stress · Selenium · Spleen · Superoxide dismutase · Chemistry · Medicine · Mycotoxins in Agriculture and Food · Rabbits: Nutrition, Reproduction, Health · Selenium in Biological Systems · Biochemistry · Endocrinology · Food Science · Immunology · Internal Medicine · Pharmacology
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| Citations per year | 0.5 |
|---|---|
| Citation span | 2014 - 2022 (9) |
| Highly cited | No |