Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn
Bibliographic Data
| ID | 15514854 |
|---|---|
| Authors | Xi Peng (0000-0001-8285-2757, Sichuan Agricultural University), Keying Zhang (0000-0002-2909-3357, Sichuan Agricultural University, corresponding author), Shiping Bai (0000-0002-5775-1900, Sichuan Agricultural University), Xuemei Ding (0000-0003-4298-4493, Sichuan Agricultural University), Qiufeng Zeng (0000-0002-7184-0432, Sichuan Agricultural University), Jun Yang (0000-0001-6740-4358, Sichuan Agricultural University), Jing Fang (0000-0002-1589-4188, Sichuan Agricultural University), Kejie Chen (0000-0003-2207-6885, Sichuan Agricultural University) |
| Year | 2014 |
| Volume | 11 |
| Issue | 8 |
| Pages | 8567-8580 |
| Publication date | 2014-08-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph110808567 |
| PMID | 25141002 |
| OpenAlex | W2086148377 |
| Language | EN |
| References cited | 34 |
The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups with six replicates per group and 30 birds per replicate. The experiment lasted for 6 weeks and the five dietary treatments consisted of control, 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The histopathological spleen lesions from the contaminated corn groups was characterized as congestion of red pulp, increased necrotic cells and vacuoles in the splenic corpuscle and periarterial lymphatic sheath. The contaminated corn intake significantly increased relative weight of spleen, percentages of apoptotic splenocytes, induced cell cycle arrest of splenocytes, increased the percentages of CD3+CD8+ T cells and decreased the ratios of CD3+CD4+ to CD3+CD8+. The results suggest that AFB-induced immunosuppression maybe closely related to the lesions of spleen
Aflatoxin · Andrology · Apoptosis · Biology · CD8 · Corn oil · Immune system · Immunosuppression · Lymphatic system · Red pulp · Spleen · Splenocyte · Immunotoxicology and immune responses · Medicine · Microbial infections and disease research · Mycotoxins in Agriculture and Food · Biochemistry · Food Science · Immunology
| Highly cited | No |
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