Racial Difference in the Association of Long-Term Exposure to Fine Particulate Matter (PM2.5) and Cardiovascular Disease Mortality among Renal Transplant Recipients

Bibliographic Data

ID15470705
AuthorsSalem Dehom (0000-0003-3211-0709, Loma Linda University, corresponding author), Synnove F Knutsen (0000-0001-8507-1745, Loma Linda University), Synnove Knutsen (Loma Linda University), Khaled Bahjri (0000-0002-4422-1687, Loma Linda University), David Shavlik (0000-0002-9824-3670, Loma Linda University), Keiji Oda (0000-0001-7631-6085, Loma Linda University), Hatem Ali (0000-0002-7306-3454, University of Redlands), Lance R Pompe (0000-0001-7810-2048, Loma Linda University), Lance Pompe (Loma Linda University), Rhonda Spencer-Hwang (Loma Linda University)
Year2021
Volume18
Issue8
Pages4297-4297
Publication date2021-04-18
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18084297
PMID33919563
OpenAlexW3152647353
LanguageEN
Citations received1
References cited54

Ambient air pollutants are known risk factors for cardiovascular disease (CVD) morbidity and mortality with significant racial disparities. However, few studies have explored racial differences among highly susceptible subpopulations, such as renal transplant recipients (RTRs). Despite improvements in quality of life after transplantation, CVD remains the major cause of mortality, especially among Black recipients. This study aimed to evaluate potential racial differences in the association between long-term levels of PM 2.5 and the risk of all-cause, total CVD, and coronary heart disease (CHD) mortality among RTRs. This retrospective study consists of 93,857 non-smoking adults who received a renal transplant between 2001 and 2015. Time-dependent Cox regression was used to assess the association between annual concentrations of PM 2.5 and mortality risk. In the multivariable-adjusted models, a 10 μg/m 3 increase in ambient PM 2.5 levels found increased risk of all-cause (HR = 3.45, 95% CI: 3.08-3.78), CVD (HR = 2.38, 95% CI: 1.94-2.92), and CHD mortality (HR = 3.10, 95% CI: 1.96-4.90). Black recipients had higher risks of all-cause (HR = 4.09, 95% CI: 3.43-4.88) and CHD mortality (HR = 6.73, 95% CI: 2.96-15.32). High levels of ambient PM 2.5 were associated with all-cause, CVD, and CHD mortality. The association tended to be higher among Black recipients than non-Blacks

Disease · Mortality rate · Proportional hazards model · Air Quality and Health Impacts · Climate Change and Health Impacts · Energy and Environment Impacts · Medicine · Internal Medicine · Transplantation

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