A Study of Handling Cytotoxic Drugs and Risk of Birth Defects in Offspring of Female Veterinarians
Bibliographic Data
| ID | 15478481 |
|---|---|
| Authors | Adeleh Shirangi (0000-0002-4842-5513, The Kids Research Institute Australia, corresponding author), Carol Bower (0000-0003-1138-2756, The Kids Research Institute Australia), Caitlin Holman (0000-0002-8075-2821, The University of Western Australia), David B Preen (0000-0002-2982-2169, The University of Western Australia), N W Bruce (The University of Western Australia) |
| Year | 2014 |
| Volume | 11 |
| Issue | 6 |
| Pages | 6216-6230 |
| Publication date | 2014-06-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph110606216 |
| PMID | 24927037 |
| OpenAlex | W2092428711 |
| Language | EN |
| References cited | 4 |
We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies) who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies and exposure during each pregnancy was obtained by self-administered mailed questionnaire. Female veterinarians handling cytotoxic drugs during their pregnancy had a two-fold increased risk of birth defects in their offspring (RR = 2.08, 95% CI (1.05-4.15)). Results were consistent in subgroup analysis of those who graduated during the period of 1961 to 1980 (RR = 5.04, 95% CI (1.81, 14.03) and in those working specifically in small and large animal practice. There was no increased risk in the subgroup that graduated after 1980. Women with unplanned pregnancies were more likely to handle cytotoxic drugs on a daily basis (RR = 1.86, 95% CI, 1.00-3.48) and had a higher increased risk of birth defects than those who planned their pregnancies in recent graduates and in those who worked specifically in small animal practice (RR = 2.53, 95% CI, 1.18-5.42). This study suggests that the adverse effects of handling cytotoxic drugs in pregnant women may include an increased risk of birth defects. Pregnancy intention status is an important health behavior and should be considered in prenatal programs
Biology · Cohort · Cohort study · Confidence interval · Drugs in pregnancy · Fetus · Obstetrics · Offspring · Pregnancy · Relative risk · Chemical Safety and Risk Management · Medicine · Pharmaceutical studies and practices · Safe Handling of Antineoplastic Drugs · Internal Medicine
Estimating the Relative Risk in Cohort Studies and Clinical Trials of Common Outcomes
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
Association Between Pregnancy Intention and Reproductive-health Related Behaviors Before and After Pregnancy Recognition, National Birth Defects Prevention Study, 1997–2002
Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome
| Highly cited | No |
|---|