Environmental Exposure to Triclosan and Semen Quality
Bibliographic Data
| ID | 15480370 |
|---|---|
| Authors | Wenting Zhu (0000-0002-2206-3147, Shanghai Jiao Tong University), Hao Zhang (0000-0003-0232-5565, Shanghai Jiao Tong University), Chuanliang Tong (International Peace Maternity & Child Health Hospital), Chong Xie (0000-0002-6726-6570, International Peace Maternity & Child Health Hospital), Guohua Fan (0000-0003-2950-191X, International Peace Maternity & Child Health Hospital), Shasha Zhao (0000-0001-8993-4915, Shanghai Jiao Tong University), Xiaogang Yu (0000-0002-7406-4256, Shanghai Jiao Tong University), Ying Tian (0000-0002-8841-9185, Shanghai Jiao Tong University), Jun Zhang (0000-0003-1706-1611, Shanghai Jiao Tong University, corresponding author) |
| Year | 2016 |
| Volume | 13 |
| Issue | 2 |
| Pages | 224-224 |
| Publication date | 2016-02-17 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph13020224 |
| PMID | 26901211 |
| OpenAlex | W2284881700 |
| Language | EN |
| Citations received | 3 |
| References cited | 39 |
Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine)(-1) (interquartile range, 0.41-2.95 ng (mg·creatinine)(-1)). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient β = -0.17; 95% confidence interval (CI) (-0.32, -0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (β = -0.35; 95% CI (-0.68, -0.03)), percentage of sperms with normal morphology (β = -1.64; 95% CI (-3.05, -0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings
Andrology · Animal science · Biology · Confidence interval · Creatinine · Infertility · Interquartile range · Pregnancy · Semen · Semen Analysis · Semen quality · Sperm · Toxicant · Toxicity · Urine · Effects and risks of endocrine disrupting chemicals · Medicine · Pharmaceutical and Antibiotic Environmental Impacts · Toxic Organic Pollutants Impact · Internal Medicine · Physiology
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,43 |
| Citation span | 2019 - 2025 (7) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |