Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
Bibliographic Data
| ID | 15480787 |
|---|---|
| Authors | Hyung‐Jun Yoon (0000-0003-3087-8853, Chosun University Hospital), Seung-Gon Kim (0000-0002-5000-7222, Chosun University Hospital), Sang Hoon Kim (0000-0003-0098-070X, Chosun University Hospital), Jong Inn Woo (0000-0001-6473-0449, Seoul National University Hospital), Eun Hyun Seo (0000-0002-4764-7464, Chosun University, corresponding author), For the Alzheimer’s Disease Neuroimaing Initiative |
| Year | 2021 |
| Volume | 18 |
| Issue | 22 |
| Pages | 12159-12159 |
| Publication date | 2021-11-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph182212159 |
| PMID | 34831913 |
| OpenAlex | W3217486258 |
| Language | EN |
| References cited | 44 |
The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer's Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [ 18 F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, p = 0.028, 95% CI 0.167-0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia
Alzheimer's disease · Cognitive reserve · Dementia · Disease · Pathology · Alzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology
Diagnostic and Statistical Manual of Mental Disorders
Cognitive reserve in ageing and Alzheimer's disease
Clinical diagnosis of Alzheimer's disease
Whitepaper
What is cognitive reserve? Theory and research application of the reserve concept
Measurement of Functional Activities in Older Adults in the Community
Brain development in children and adolescents
| Citation velocity | historical |
|---|---|
| Highly cited | No |