Risk Factors for Lung Cancer in the Province of Lecce
Results from the PROTOS Case–Control Study in Salento (Southern Italy)
Bibliographic Data
| ID | 15480865 |
|---|---|
| Authors | Fabrizio Minichilli (0000-0003-0007-4731, Istituto di Fisiologia Clinica, corresponding author), Francesca Gorini (0000-0002-4619-6227, Istituto di Fisiologia Clinica), Giovanni De Filippis, Elisa Bustaffa (0000-0002-1601-033X, Istituto di Fisiologia Clinica), Anna Maria Raho, Anna Melcarne, F Quarta, Giuseppe Maggiore (0000-0001-8201-2416), Adele Idolo (0000-0002-6049-1986), Francesca Serio (0000-0002-0031-4208, University of Salento), Tiziana Grassi (0000-0003-1200-2778, University of Salento), Francesco Bagordo (0000-0001-5208-5382, University of Salento), Idelberto Francesco Castorini, Giovanni Imbriani (0000-0002-2677-5395, University of Salento), Fabrizio Bianchi (0000-0002-3459-9301, Istituto di Fisiologia Clinica), Prisco Piscitelli (0000-0003-4556-6182) |
| Year | 2022 |
| Volume | 19 |
| Issue | 14 |
| Pages | 8775-8775 |
| Publication date | 2022-07-19 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19148775 |
| PMID | 35886627 |
| OpenAlex | W4285798930 |
| Language | EN |
| References cited | 9 |
In the province of Lecce (southern Italy), a higher incidence of lung cancer (LC) among men compared to regional and national data was reported. In a sub-area in the center of the province (cluster area), the incidence and mortality for LC was even higher. PROTOS is a case-control study aimed at investigating possible risk factors for LC in the province area. A total of 442 patients with LC and 1326 controls matched by sex and age living in the province of Lecce for at least 10 years were enrolled and georeferenced; they filled in a questionnaire with their personal information and exposures. For each risk factor, an Odds Ratio adjusted for all the other variables was calculated. The risk of LC increased with excessive use of alcohol in women, for those subjects with a family cancer history, for each increase in pack/year of cigarettes, for men more exposed considering the industrial district in the cluster area, and for those using pesticides in agriculture without wearing personal protective equipment. The higher incidence of adenocarcinoma in both sexes suggests that, in addition to cigarette smoking, concurrent exposures to other environmental, occupational, and life-style factors may play a role in increased cancer risk and should be more deeply explored
Environmental health · Geography · Lung cancer · Sociology · Demography · Global Cancer Incidence and Screening · Lung Cancer Diagnosis and Treatment · Lung Cancer Treatments and Mutations · Medicine · Oncology
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| Citation velocity | historical |
|---|---|
| Highly cited | No |