Sex-Specific Association between Metabolic Abnormalities and Elevated Alanine Aminotransferase Levels in a Military Cohort

The CHIEF Study

Bibliographic Data

ID15488232
AuthorsKaiwen Chen (0000-0002-5195-220X, Hualien Armed Forces General Hospital), Kai-Wen Chen (Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jin-Feng St., Hualien 970, Taiwan), Fan‐Chun Meng (Tri-Service General Hospital), Fan-Chun Meng (Departments of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan), Yu‐Lueng Shih (0000-0003-4629-4393, Tri-Service General Hospital), Yu-Lueng Shih (Departments of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan), Fang‐Ying Su (0000-0002-5103-7431, Tzu Chi University), Fang-Ying Su (Tzu Chi University), Yen‐Po Lin (0000-0002-0827-7368, Fu Jen Catholic University), Yen-Po Lin (Fu Jen Catholic University), Felicia Lin (Hualien Armed Forces General Hospital), Jia‐Wei Lin (0000-0002-3311-5379, National Yang Ming Chiao Tung University), Jia-Wei Lin (0000-0001-9443-0340, National Yang Ming University), Wei‐Kuo Chang (0000-0002-5738-2797, Tri-Service General Hospital), Wei-Kuo Chang (Departments of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan), Chung‐Jen Lee (0000-0003-1418-224X, Tzu Chi College of Technology), Chung-Jen Lee (Tzu Chi College of Technology), Yi-Hwei Li (Tzu Chi University), Chung-Bao Hsieh (Tri-Service General Hospital), Gen‐Min Lin (0000-0002-5509-1056, Tri-Service General Hospital, corresponding author), Gen-Min Lin (Department of Medicine, Hualien Armed Forces General Hospital, No. 100, Jin-Feng St., Hualien 970, Taiwan)
Year2018
Volume15
Issue3
Pages545-545
Publication date2018-03-19
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph15030545
PMID29562671
OpenAlexW2789777688
LanguageEN
Citations received6
References cited33

The association of metabolic syndrome (MetS) components with elevated serum alanine aminotransferase (ALT) levels, a marker of hepatic injury, may differ between men and women. However, the sex-specific association in a military young population which has a low prevalence of MetS was unclear. We conducted a cross-sectional examination in 6738 men and 766 women, aged 18-50 years, from the cardiorespiratory fitness study in armed forces (CHIEF) in eastern Taiwan. The components of MetS were defined according to the updated International Diabetes Federation (IDF) ethnic criteria for Asians. Elevated ALT levels were defined as ≥40 U/L for both sexes and ≥30 U/L for women alternatively. Multivariate logistic regression analysis was performed to determine the sex-specific association between MetS components and elevated ALT. The prevalence of MetS and elevated ALT in men were 11.9% and 12.7% respectively, and in women were 3.5%, and 3.8% respectively. In men, high-density lipoprotein p p = 0.001) and ALT ≥ 30 U/L (2.67 (0.89-7.95), p = 0.08). Our findings suggest that the relationship between metabolic abnormalities and elevated ALT may differ by sex, possibly due to the MetS more prevalent in young adult men than in women

Alanine aminotransferase · Alanine transaminase · Body mass index · Cardiorespiratory fitness · Cohort · Confidence interval · Cross-sectional study · Logistic regression · Metabolic syndrome · Obesity · Odds ratio · Pathology · Population · Waist · Demography · Diabetes, Cardiovascular Risks, and Lipoproteins · Liver Disease Diagnosis and Treatment · Medicine · Metabolism, Diabetes, and Cancer · Endocrinology · Gastroenterology · Internal Medicine

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