Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males

The CHIEF Study

Bibliographic Data

ID15500315
AuthorsPang‐Yen Liu (Tri-Service General Hospital), Pang-Yen Liu (0000-0002-3318-9757, Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Tokyo 113-0033, Japan), Yu‐Kai Lin (0000-0002-2668-9833), Yu-Kai Lin (0000-0002-8995-8375, Tri-Service General Hospital), Kaiwen Chen (0000-0002-5195-220X, Hualien Armed Forces General Hospital), Kai-Wen Chen (Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan), Kun‐Zhe Tsai (0000-0002-7126-1545, Hualien Armed Forces General Hospital), Kun-Zhe Tsai (Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan), Yen‐Po Lin (0000-0002-0827-7368, Tri-Service General Hospital), Yen-Po Lin (Department of Critical Care Medicine, Taipei Tzu-Chi General Hospital, New Taipei City 231, Taiwan), Eiki Takimoto (0000-0001-7767-0094, The University of Tokyo), Gen‐Min Lin (0000-0002-5509-1056, Northwestern University, corresponding author)
Year2020
Volume17
Issue17
Pages6094-6094
Publication date2020-08-21
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17176094
PMID32825751
OpenAlexW3080223009
LanguageEN
References cited43

Background : An inverse relationship of serum liver transaminases and mortality might be due to better blood pressure control in hypertensive patients. Whether it holds true regarding such an association for long-term blood pressure variability (BPV) in those without antihypertensive therapy is unclear. Methods : A population of 1112 military males without antihypertensive medications, aged 32 years, was collected from a retrospective longitudinal study in Taiwan. Serum liver aspartate and alanine transaminase (AST and ALT) levels were obtained from a 12 h-fast blood sample of each participant. BPV was assessed by standard deviation (SD) and average real variability (ARV) of systolic and diastolic blood pressure (SBP and DBP), respectively across 4 visits during the study period (2012-2014, 2014-2015, 2015-2016, and 2016-2018). Multivariable linear regression analysis was utilized to determine the association adjusting for demographics, anthropometric indexes, SBP, DBP, and lipid profiles. Results : In the unadjusted model, ALT was significantly and positively correlated with SD DBP and ARV DBP (β (standard errors) = 0.36 (0.16) and 0.24 (0.12), respectively), and so was AST (β = 0.19 (0.08) and 0.14 (0.06), respectively). All the associations were insignificant with adjustments. However, ALT was significantly and negatively correlated with SD SBP and ARV SBP (β = -0.35 (0.14) and -0.25 (0.11), respectively) and so was AST (β = -0.14 (0.07) and -0.12 (0.06), respectively) with adjustments. Conclusion : Our findings suggested that serum liver transaminases were negatively correlated with long-term systolic BPV in young male adults without antihypertensive therapy, and the clinical relevance needs further investigations

Alanine aminotransferase · Alanine transaminase · Anthropometry · Aspartate transaminase · Biology · Blood pressure · Diastole · Population · Transaminase · Diet, Metabolism, and Disease · Liver Disease and Transplantation · Liver Disease Diagnosis and Treatment · Medicine · Gastroenterology · Internal Medicine

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