Characterization of Chromosome-Mediated BlaOXA-894 in Shewanella xiamenensis Isolated from Pig Wastewater
Bibliographic Data
| ID | 15488799 |
|---|---|
| Authors | Huiyun Zou (0000-0002-6021-8330, Shandong University), Ziyu Zhou (0000-0002-5116-1125, Shandong University), Huiyu Xia (0000-0002-4440-4096, Shandong University), Qian Zhao (0000-0003-1760-249X, Shandong University), Xuewen Li (0000-0003-1610-9812, Shandong University, corresponding author) |
| Year | 2019 |
| Volume | 16 |
| Issue | 19 |
| Pages | 3768-3768 |
| Publication date | 2019-10-08 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph16193768 |
| PMID | 31597235 |
| OpenAlex | W2977747429 |
| Language | EN |
| References cited | 24 |
A new variant of the bla OXA-546 gene, namely bla OXA-894 , was identified on the chromosome of Shewanella xiamenensis isolated from pig wastewater in rural China. OXA-894 differs from OXA-546 (A46V, I219 del ) and OXA-48 (T167I, I219 del ) with two amino acid substitutions, respectively. The isolate was resistant to ampicillin, aztreonam, imipenem, meropenem and fosfomycin. Carba NP test confirmed S. xiamenensis strain sx20 as a carbapenemase-producer. The bla OXA-894 gene was located between the gene encoding a LysR family transcriptional regulator and the C15 gene. Its gene environment was similar to other S. xiamenensis with chromosome-located bla OXA-48 -like genes. The T24H and T94V amino acid substitutions of LuxS protein were predicted to be deleterious, which may affect the virulence phenotype. The occurrence and potential health risk of carbapenem-resistant S. xiamenensis in a water environment is of concern
Antibiotic resistance · Antibiotics · Aztreonam · Bacteria · Biology · Chromosome · Fosfomycin · Gene · Imipenem · Meropenem · Pseudomonas aeruginosa · Virulence · Antibiotic Resistance in Bacteria · Bacterial biofilms and quorum sensing · Infections and bacterial resistance · Genetics · Microbiology
| Highly cited | No |
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