Sars-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital

Bibliographic Data

ID15489698
AuthorsArmando De Carlo (0000-0002-4665-8612, Ospedali Riuniti di Foggia), Sergio Lo Caputo (0000-0002-4729-7548, University of Foggia), Carmela Paolillo (0000-0003-2677-5747, University of Foggia), Anna Rosa (0000-0002-0247-6593, Ospedali Riuniti di Foggia), Anna Maria Rosa (Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy), Umberto D’Orsi (Ospedali Riuniti di Foggia), María Fátima Palma (0000-0003-0936-0523, Ospedali Riuniti di Foggia), Maria De Palma (Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy), Pierluigi Reveglia (0000-0003-0588-2092, University of Foggia), Donato Lacedonia (0000-0003-0429-7967, University of Foggia), Gilda Cinnella (0000-0001-9864-2893, University of Foggia), Maria Pia Foschino Barbaro (0000-0001-9939-2697, University of Foggia), Maria Pia Foschino (Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy), Maurizio Margaglione (0000-0001-5627-9221, University of Foggia), Lucia Mirabella (0000-0001-8430-5239, Ospedali Riuniti di Foggia), Teresa Santantonio (0000-0002-4342-6904, University of Foggia), Gaetano Corso (0000-0003-4720-1320, University of Foggia, corresponding author), Vitangelo Dattoli (Ospedali Riuniti di Foggia)
Year2020
Volume17
Issue24
Pages9324-9324
Publication date2020-12-13
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17249324
PMID33322150
OpenAlexW3113312532
LanguageEN
Citations received2
References cited14

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the first coronavirus that has caused a pandemic. Assessing the prevalence of anti-SARS-CoV-2 in healthcare worker groups offers a unique opportunity to study the correlation between seroconversion and immunization because of their occupational exposure and a higher risk of contagion. The study enrolled 3242 asymptomatic employees of "Policlinico Riuniti", Foggia. After the first screening, we collected sequential serum samples for up to 23 weeks from the same subjects. In order to perform a longitudinal follow-up study and get information about the titration of IgG levels, we analyzed data from subjects (33) with at least two consecutive serological IgG-positive tests; 62 (1.9%; 95% CI: 1.4-2.3) tested positive for at least one anti-SARS-CoV-2 antibody. The seroprevalence was lower in the high-risk group 1.4% (6/428; 95% CI: 0.5-2.6) vs. the intermediate-risk group 2.0% (55/2736; 95% CI: 1.5-2.5). Overall, within eight weeks, we detected a mean reduction of -17% in IgG levels. Our data suggest a reduction of about 9.27 AU/mL every week (R 2 = 0.35, p = 0.0003). This study revealed the prevalence of SARS-CoV-2 antibodies among Foggia's hospital healthcare staff (1.9%). Moreover, the IgG level reduction suggests that the serological response fades fast in asymptomatic infections

Antibody · Asymptomatic · Coronavirus disease 2019 (COVID-19 · Disease · Health care · Infectious disease (medical specialty · Seroconversion · Serology · Seroprevalence · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 · Subclinical infection · COVID-19 Clinical Research Studies · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Immunology · Internal Medicine

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