The Associations of Trans-3′-Hydroxy Cotinine, Cotinine, and the Nicotine Metabolite Ratio in Pediatric Patients with Tobacco Smoke Exposure
Bibliographic Data
| ID | 15499124 |
|---|---|
| Authors | E Melinda Mahabee‐Gittens (0000-0002-3893-885X, Cincinnati Children's Hospital Medical Center, corresponding author), Georg E Matt (0000-0001-5604-4609, San Diego State University), Roman Jandarov (0000-0003-2145-045X, University of Cincinnati Medical Center), Roman A Jandarov (Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA), Ashley L Merianos (0000-0002-5640-7227, University of Cincinnati) |
| Year | 2023 |
| Volume | 20 |
| Issue | 9 |
| Pages | 5639-5639 |
| Publication date | 2023-04-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph20095639 |
| PMID | 37174159 |
| OpenAlex | W4367054523 |
| Language | EN |
| References cited | 38 |
(1) Background: Trans -3'-hydroxy cotinine (3HC) and cotinine (COT) are tobacco smoke exposure (TSE) biomarkers and the 3HC/COT ratio is a marker of CYP2A6 activity, an enzyme which metabolizes nicotine. The primary objective was to assess the associations of these TSE biomarkers with sociodemographics and TSE patterns in children who lived with ≥1 smoker. (2) Methods: A convenience sample of 288 children (mean age (SD) = 6.42 (4.8) years) was recruited. Multiple linear regression models were built to assess associations of sociodemographics and TSE patterns with urinary biomarker response variables: (1) 3HC, (2) COT, (3) 3HC+COT sum, and (4) 3HC/COT ratio. (3) Results: All children had detectable 3HC (Geometric Mean [GeoM] = 32.03 ng/mL, 95%CI = 26.97, 38.04) and COT (GeoM = 10.24 ng/mL, 95%CI = 8.82, 11.89). Children with higher cumulative TSE had higher 3HC and COT (β^ = 0.03, 95%CI = 0.01, 0.06, p = 0.015 and β^ = 0.03, 95%CI = 0.01, 0.05, p = 0.013, respectively). Highest 3HC+COT sum levels were in children who were Black (β^ = 0.60, 95%CI = 0.04, 1.17, p = 0.039) and who had higher cumulative TSE (β^ = 0.03, 95%CI = 0.01, 0.06, p = 0.015). Lowest 3HC/COT ratios were in children who were Black (β^ = -0.42, 95%CI = -0.78, -0.07, p = 0.021) and female (β^ = -0.32, 95%CI = -0.62, -0.01, p = 0.044). (4) Conclusion: Results indicate that there are racial and age-related differences in TSE, most likely due to slower nicotine metabolism in non-Hispanic Black children and in younger children
Cotinine · CYP2A6 · Environmental health · Metabolism · Metabolite · Nicotine · Tobacco smoke · Air Quality and Health Impacts · Health, Environment, Cognitive Aging · Medicine · Smoking Behavior and Cessation · Internal Medicine
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers
Tobacco Product Use Among Adults — United States, 2020
Biochemical Verification of Tobacco Use and Abstinence
Quitting Smoking Among Adults — United States, 2000–2015
Cotinine as a Biomarker of Environmental Tobacco Smoke Exposure
A Parental Smoking Cessation Intervention in the Pediatric Emergency Setting
Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children
Healthy families
| Citation velocity | historical |
|---|---|
| Highly cited | No |